肖云，教授，博士研究生，生物信息学院副院长。
团队网站:http://biocc.hrbmu.edu.cn/xteam/
E-mail：xiaoyun@ems.hrbmu.edu.cn，
主要研究方向
癌症演化组学大数据研究。
个人简介
黑龙江省“龙江学者”青年学者、黑龙江省领军人才梯队后备带头人、黑龙江省“头雁”计划骨干成员、中国细胞生物学学会功能基因组信息学与系统生物学分会委员、中华预防医学会生物信息学分会委员、黑龙江省生物信息学学会副理事长、黑龙江省人工智能学会理事、国自然科学基金函评专家，国际著名杂志《Heliyon》杂志副主编、《Molecular Medicine Reports》杂志编委、《International Journal of Genetics Frontiers》杂志编委等国际期刊论文评审专家。
主要从事以肿瘤演化为核心的生物信息学研究，以第一作者或通讯作者身份发表SCI论文80篇，全部论文累计他引近四千次。先后承担国家自然基金重点支持项目、面上项目、黑龙江省优秀青年项目等科研课题22项。作为主要参加者编写国家卫生部规划教材《生物信息学》（第1、2、3版）、《生物信息学学习指导与习题集》（第1、2、3版）和生物医学专业教材《生物信息学理论与医学实践》，受Springer出版社邀请编写《Non-coding RNAs in Complex Diseases》等近10部教材与专著。
主持和参加国家级教学课题1项、省级课题3项。指导13届120余名本科生（包括2名留学生）顺利完成毕业设计，多次被评为校优秀本科毕业生指导教师，学生论文多次被评为优秀毕业论文，培养的毕业生被哈尔滨医科大学、清华大学、北京大学、复旦大学和同济大学等知名院校录取为研究生继续深造。辅导及协助辅导13届30多名硕博研究生顺利毕业，指导研究生发表多篇高水平SCI论文并多次获得国家奖学金和优秀毕业生称号。
科研项目（仅列国家级）
1.联合基金重点支持项目：融合寒地高发恶性肿瘤组学数据识别癌症演化早期重要驱动因子(U21A20196)，260万；
2.面上项目：基于癌症克隆进化解析癌基因的功能异质性(31871336)，60万；
3.面上项目：解析人类癌症风险非编码RNA（miRNA/lncRNA）协同调控网络及其功能分析(61573122)，66万；
4.基金青年项目：整合多组学数据揭示胚胎干细胞特异的转录调控与染色质状态交联模式(31200997)，20万；
发表SCI论文104篇，其中高水平论文（SCI影响因子>10）25篇
1.Quan, F., X. Liang, M. Cheng, H. Yang, K. Liu, S. He, S. Sun, M. Deng, Y. He, W. Liu, S. Wang, S. Zhao, L. Deng, X. Hou, X. Zhang, and Y. Xiao, Annotation of cell types (ACT): a convenient web server for cell type annotation. Genome Med, 2023. 15(1): p. 91.(SCI IF:12.3)
2.Liu, K., S. He, S. Sun, X. Zhang, Y. He, F. Quan, B. Pang, and Y. Xiao, Computational Quantification of Cancer Immunoediting. Cancer Immunol Res, 2023. 11(9): p. 1159-1167.(SCI IF:12.02)
3.Liao, G., Z. Jiang, Y. Yang, C. Zhang, M. Jiang, J. Zhu, L. Xu, A. Xie, M. Yan, Y. Zhang, Y. Xiao, and X. Li, Combined homologous recombination repair deficiency and immune activation analysis for predicting intensified responses of anthracycline, cyclophosphamide and taxane chemotherapy in triple-negative breast cancer. BMC Med, 2021. 19(1): p. 190.(SCI IF:11.15)
4.Zhang X, Lan Y, Xu J, Quan F, Zhao E, Deng C, Luo T, Xu L, Liao G, Yan M, Ping Y, Li F, Shi A, Bai J, Zhao T, Li X, XiaoY. CellMarker: a manually curated resource of cell markers in human and mouse. Nucleic Acids Res. 2019;47(D1):D721-D8.(SCI: 19.16)
5.Xu L, Zhu S, Lan Y, Yan M, Jiang Z, Zhu J, Liao G, Ping Y, Xu J, Pang B, Zhang Y, Xiao Y, Li X. Revealing the contribution of somatic gene mutations to shaping tumor immune microenvironment. Brief Bioinform. 2022;23(3).(SCI: 13.994)
6.Yan M, Hu J, Yuan H, Xu L, Liao G, Jiang Z, Zhu J, Pang B, Ping Y, Zhang Y, Xiao Y, Li X. Dynamic regulatory networks of T cell trajectory dissect transcriptional control of T cell state transition. Mol Ther Nucleic Acids. 2021;26:1115-29.(SCI: 10.183)
7.Wu J, Zhang L, Song Q, Yu L, Wang S, Zhang B, Wang W, Xia P, Chen X, Xiao Y, Xu C. Systematical identification of cell-specificity of CTCF-gene binding based on epigenetic modifications. Brief Bioinform. 2021;22(1):589-600.(SCI: 13.994)
8.Ping Y, Zhou Y, Hu J, Pang L, Xu C, Xiao Y. Dissecting the Functional Mechanisms of Somatic Copy-Number Alterations Based on Dysregulated ceRNA Networks across Cancers. Mol Ther Nucleic Acids. 2020;21:464-79.(SCI: 10.183)
9.Zhang X, Quan F, Xu J, Xiao Y, Li X, Li Y. Combination of multiple tumor-infiltrating immune cells predicts clinical outcome in colon cancer. Clin Immunol. 2020;215:108412.(SCI: 10.19)
10.Zhao H, Shi J, Zhang Y, Xie A, Yu L, Zhang C, Lei J, Xu H, Leng Z, Li T, Huang W, Lin S, Wang L, Xiao Y, Li X. LncTarD: a manually-curated database of experimentally-supported functional lncRNA-target regulations in human diseases. Nucleic Acids Res. 2020;48(D1):D118-D26.(SCI: 19.16)
11.Yu F, Quan F, Xu J, Zhang Y, Xie Y, Zhang J, Lan Y, Yuan H, Zhang H, Cheng S, Xiao Y, Li X. Breast cancer prognosis signature: linking risk stratification to disease subtypes. Brief Bioinform. 2019;20(6):2130-40.(SCI: 13.994)
12.Zhang Y, Liao G, Bai J, Zhang X, Xu L, Deng C, Yan M, Xie A, Luo T, Long Z, Xiao Y, Li X. Identifying Cancer Driver lncRNAs Bridged by Functional Effectors through Integrating Multi-omics Data in Human Cancers. Mol Ther Nucleic Acids. 2019;17:362-73.(SCI: 10.183)
13.Zhang H, Liao J, Zhang X, Zhao E, Liang X, Luo S, Shi J, Yu F, Xu J, Shen W, Li Y, Xiao Y, Li X. Sex difference of mutation clonality in diffuse glioma evolution. Neuro Oncol. 2019;21(2):201-13.(SCI: 13.029)
14.Deng Y, Luo S, Deng C, Luo T, Yin W, Zhang H, Zhang Y, Zhang X, Lan Y, Ping Y, Xiao Y, Li X. Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability. Brief Bioinform. 2019;20(1):254-66.(SCI: 13.994)
15.Yuan H, Yan M, Zhang G, Liu W, Deng C, Liao G, Xu L, Luo T, Yan H, Long Z, Shi A, Zhao T, Xiao Y, Li X. CancerSEA: a cancer single-cell state atlas. Nucleic Acids Res. 2019;47(D1):D900-D8.(SCI: 19.16)
16.Xu L, Deng C, Pang B, Zhang X, Liu W, Liao G, Yuan H, Cheng P, Li F, Long Z, Yan M, Zhao T, Xiao Y, Li X. TIP: A Web Server for Resolving Tumor Immunophenotype Profiling. Cancer Res. 2018;78(23):6575-80.(SCI: 13.312)
17.Xu J, Shi A, Long Z, Xu L, Liao G, Deng C, Yan M, Xie A, Luo T, Huang J, Xiao Y, Li X. Capturing functional long non-coding RNAs through integrating large-scale causal relations from gene perturbation experiments. EBioMedicine. 2018;35:369-80.(SCI: 11.205)
18.Zhang H, Luo S, Zhang X, Liao J, Quan F, Zhao E, Zhou C, Yu F, Yin W, Zhang Y, Xiao Y, Li X. SEECancer: a resource for somatic events in evolution of cancer genome. Nucleic Acids Res. 2018;46(D1):D1018-D26.(SCI: 19.16)
19.Zhang G, Shi J, Zhu S, Lan Y, Xu L, Yuan H, Liao G, Liu X, Zhang Y, Xiao Y, Li X. DiseaseEnhancer: a resource of human disease-associated enhancer catalog. Nucleic Acids Res. 2018;46(D1):D78-D84.(SCI: 19.16)
20.Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, Ren H. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ. 2017;24(5):929-43.(SCI: 15.828)
21.Xu J, Bai J, Zhang X, Lv Y, Gong Y, Liu L, Zhao H, Yu F, Ping Y, Zhang G, Lan Y, Xiao Y, Li X. A comprehensive overview of lncRNA annotation resources. Brief Bioinform. 2017;18(2):236-49.(SCI: 13.994)
22.Zhang H, Deng Y, Zhang Y, Ping Y, Zhao H, Pang L, Zhang X, Wang L, Xu C, Xiao Y, Li X. Cooperative genomic alteration network reveals molecular classification across 12 major cancer types. Nucleic Acids Res. 2017;45(2):567-82.(SCI: 19.16)
23.Xiao, Y., Y. Ping, H. Fan, C. Xu, J. Guan, H. Zhao, Y. Li, Y. Lv, Y. Jin, L. Wang, and X. Li, Identifying dysfunctional miRNA-mRNA regulatory modules by inverse activation, cofunction, and high interconnection of target genes: a case study of glioblastoma. Neuro Oncol, 2013. 15(7): p. 818-28.(SCI IF:15.9)
24.Xiao, Y., J. Guan, Y. Ping, C. Xu, T. Huang, H. Zhao, H. Fan, Y. Li, Y. Lv, T. Zhao, Y. Dong, H. Ren, and X. Li, Prioritizing cancer-related key miRNA-target interactions by integrative genomics. Nucleic Acids Res, 2012. 40(16): p. 7653-65.(SCI IF:19.16)
25.Ping, Y., Y. Deng, L. Wang, H. Zhang, Y. Zhang, C. Xu, H. Zhao, H. Fan, F. Yu, Y. Xiao, and X. Li, Identifying core gene modules in glioblastoma based on multilayer factor-mediated dysfunctional regulatory networks through integrating multi-dimensional genomic data. Nucleic Acids Res, 2015. 43(4): p. 1997-2007.(SCI IF:19.16)
