王一涵，博士研究生，教研室科研、行政秘书。
团队网站: http://biocc.hrbmu.edu.cn/xteam/index.html?member=wangyihan
E-mail：wangyihan@hrbmu.edu.cn
主要研究方向
癌症生物信息学
个人简介
王一涵，副教授,博士生导师。2018年6月毕业于哈尔滨医科大学博士学位，同年留校参加工作。2018年-2021年在哈尔滨医科大学附属第二医院博士后流动站完成博士后工作。任职至今，承担《大数据技术》、《生物医学大数据技术》、《组合数学与图论》等课程的本科生教学工作，年均168学时。参与在线课程《基于生命组学的生物信息学》的搭建。参与黑龙江省教育科学“十四五”规划重点课题2项。指导学生获得2021年全国大学生数学建模竞赛黑龙江赛区一等奖1项，获得2021年东北三省数学建模联赛二等奖1项。主要研究方向包括从转录组、表观组层面剖析癌症的发病机制以及肿瘤微环境对瘤内异质性的影响，筛选癌症诊断、治疗及预后的生物标记物。先后主持国家自然科学基金青年项目1项，黑龙江省博士后科研启动金项目1项，校创新基金1项。近年来在《Theranostics》、《ScientificReports》及《PeerJ》等杂志发表SCI论文19篇，其中以第一作者及通讯作者发表SCI论文4篇，影响因子大于10的1篇。
教育经历
2008.08-2013.06哈尔滨医科大学 生物技术（生物医学软件工程方向） 学士
2013.08-2018.06哈尔滨医科大学 生物医学工程 博士
工作经历
2018.07-至今，哈尔滨医科大学，生物信息科学与技术学院，讲师
主持科研项目
(1)国家自然科学基金青年项目：基于单细胞测序数据识别乏氧微环境介导肿瘤转移的关键调控子，2023年-2025年，30万元，在研；
(2)黑龙江省博士后启动金：基于单细胞RNA-seq的胶质母细胞瘤乏氧肿瘤微环境研究，2023年-2025年，10万元，在研；
(3)哈尔滨医科大学创新基金项目：乳腺癌瘤内微环境表观遗传异质性分析，2018年-2020年，4.8万元，已结题
主持及参与教学项目
（1）黑龙江省教育科学“十四五”2021年度重点课题：基于生物医学大数据技术的生物信息学课程体系改革研究与实践，2021年-2022年，黑龙江省教育厅，参与，已结题；
（2）黑龙江省教育科学“十四五”2022年度重点课题：大数据时代生物信息学课程体系改革探索与实践，2022年-2023年，黑龙江省教育厅，参与，在研。
指导学生获奖
（1）省一等奖（指导教师），2021年，全国大学生数学建模竞赛
（2）省二等奖（指导教师），2021年，东北三省数学建模联赛
（3）省三等奖（指导教师），2022年，全国大学生数学建模竞赛
发表SCI论文
(1)Wang Yihan;Zhang Yan(*); Huang Yan; Chen Chuangeng; Zhang Xingda; Xing Ying; Gu Yue; Zhang Mengyan; Cai Li; Xu Shouping(*); Sun Baoqing(*); Intratumor heterogeneity of breast cancer detected by epialleles shows association with hypoxic microenvironment,Theranostics, 2021 Mar 4, 11(9):4403-4420
(2)Wang Yihan(#); Zhang Jingyu(#); Xiao Xingjun(#); Liu Hongbo; Wang Fang; LiSong; Wen Yanhua; Wei Yanjun; Su Jianzhong; Zhang Yunming(*); Zhang Yan(*); The identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes,Scientific Reports, 2016 Mar 7, 6(1): 0~22722
(3)Yujia Lan; Erjie Zhao; Xinxin Zhang; Xiaojing Zhu; Linyun Wan; Suru A; Yanyan Ping(*);Yihan Wang(*); Prognostic impact of a lymphocyte activation-associated gene signature in GBM based on transcriptome analysis, PeerJ, 2021, 9: e12070
(4)Chen Guang(#);Wang Yihan(#); Wang Lu; Xu Wanhai(*); Identifying prognostic biomarkers based on aberrant DNA methylation in kidney renal clear cell carcinoma,Oncotarget, 2017 Jan17, 8(3): 5268~5280
(5)Shumei Zhang;Yihan Wang; Yue Gu; Jiang Zhu; Ce Ci; Zhongfu Guo; Chuangeng Chen; Yanjun Wei; Wenhua Lv; Hongbo Liu; Dongwei Zhang (*); Yan Zhang (*); Specific breast cancer prognosis-subtype distinctions based on DNA methylation patterns,Molecular Oncology, 2018 May 21, 12(7): 1047~1060
(6)Sijia Zhang;Yihan Wang; Meijun Chen; Lulu Sun; Jun Han; V Kazakova Elena; Hong Qiao (*); CXCL12 methylation-mediated epigenetic regulation of gene expression in papillary thyroid carcinoma,Scientific Reports, 2017 Mar 8, 7(1): 0~44033
(7)Huang Yan(#); Zhou Dianshuang(#);Wang Yihan; Zhang Xingda; Su Mu; Wang Cong; Sun Zhongyi; Jiang Qinghua(*); Sun Baoqing(*); Zhang Yan(*); Prediction of transcription factors binding events based on epigenetic modifications in different human cells,Epigenomics, 2020 Sep 14, 12(16):1443-1456
(8)LiangShuang;LiZhenzhi;WangYihan;LiXiaodan;YangXiaolei;ZhanXiaolei;HuangYan;GaoZhaomin;ZhangMin;SunCaihong;ZhangYan (*);WuLijie (*);Genome-Wide DNA Methylation Analysis Reveals Epigenetic Pattern of SH2B1 in Chinese Monozygotic Twins Discordant for Autism Spectrum Disorder,Frontiers in Neuroscience, 2019 Jul 17, 13: 712
(9)Han Jun(#);Chen Meijun(#);Wang Yihan;Gong Boxuan;Zhuang Tianwei;Liang Lingyu;Qiao Hong(*);Identification of Biomarkers Based on Differentially Expressed Genes in Papillary Thyroid Carcinoma,Scientific Reports,2018Jul 2, 8(1): 0~9912
(10)Han Jun(#); Chen Meijun (#); Fang Qingxiao(#); Zhang Yanqing;WangYihan; Jamaspishvili Esma; Qiao Hong(*); Prediction of the Prognosis Based on ChromosomalInstability-Related DNA Methylation Patterns of ELOVL2 and UBAC2 in PTCs,Molecular Therapy Nucleic Acids,2019 Dec 6, 18: 650–660
(11)Yao Zhou#, Shuai Wang #, Haoteng Yan, Bo Pang, Xinxin Zhang, Lin Pang,Yihan Wang, Jinyuan Xu, Jing Hu, Yujia Lan, Yanyan Ping;Identifying Key Somatic Copy Number Alterations Driving Dysregulation of Cancer Hallmarks in Lower-Grade Glioma,Frontiers in genetics, 2021, 12: 654736
(12)Gaoming Liao , Xin Liang , Yanyan Ping , Yong Zhang , Jianlong Liao ,Yihan Wang, Xiaobo Hou , Zedong Jiang , Xiaoqiu Dong , Chaohan Xu , Yun Xiao, Revealing the subtyping of non-small cell lung cancer based on genomic evolutionary patterns by multi-region sequencing,Cancer Medicine, 2020, 9(24): 9485–9498
(13)Wang Fang (#); Zhang Shaojun(#); Liu Hongbo; Wei Yanjun;Wang Yihan; Han Xiaole; Su Jianzhong; Zhang Dongwei; Xie Baodong(*); Zhang Yan(*); CellMethy: Identification of a focal concordantly methylated pattern of CpGs revealed wide differences between normal and cancer tissues,Scientific Reports, 2015 Dec 10, 5: 0~18037
(14)Liao Gaoming(#); Liang Xin(#); Ping Yanyan; Zhang Yong; Liao Jianlong;Wang Yihan; Hou Xiaobo; Jiang Zedong; Dong Xiaoqiu(*); Xu Chaohan(*); Xiao Yun(*); Revealing the subtyping of non-small cell lung cancer based on genomic evolutionary patterns by multi-region sequencing,Cancer Medicine, 2020 Dec, 9(24):9485-9498
(15)Liu Hongbo; Li Song; Wang Xinyu; Zhu Jiang; Wei Yanjun;Wang Yihan; Wen Yanhua; Wang Libo; Huang Yan; Zhang Bin; Shang Shipeng; Zhang Yan(*); DNA methylation dynamics: identification and functional annotation,Briefings in Functional Genomics, 2016 Nov, 15(6): 470~484
(16)Xiong Yichun(#); Wei Yanjun(#); Gu Yue(#), Zhang Shumei, Lyu Jie, Zhang Bin, Chen Chuangeng, Zhu Jiang,Wang Yihan, Liu Hongbo(*), Zhang Yan(*), DiseaseMeth version 2.0: a major expansion and update of the human disease methylation database,Nucleic Acids Research, 2017 Jan 4, 45(D1): D888~D895
(17)Huihan Wang(#), Weili Yan(#), Shumei Zhang(#), Yue Gu,Yihan Wang, Yanjun Wei, Hongbo Liu, Fang Wang, Qiong Wu(*), Yan Zhang(*), Survival differences of CIMP subtypes integrated with CNA information in human breast cancer,Oncotarget, 2017,8(30): 48807–48819
(18)Chunlong Zhang(#), Xinyu Wang(#), Xuecang Li, Ning Zhao,Yihan Wang, Xiaole Han, Ce Ci, Jian Zhang, Meng Li, Yan Zhang(*),The landscape of DNA methylation-mediated regulation of long non-coding RNAs in breast cancer,Oncotarget, 2017, 8(31):51134-51150
(19)Min Zhang, Shaojun Zhang, Yanhua Wen,Yihan Wang, Yanjun Wei, Hongbo Liu, Dongwei Zhang, Jianzhong Su, Fang Wang(*), Yan Zhang(*),PLoS One, 2015, 10(11): e0142279.
