金清

    金清，博士，哈尔滨医科大学，生物信息科学与技术学院，讲师。主要研究方向是人工智能辅助药物研发以及个性化医疗相关研究。近年来发表SCI科研论文14篇（其中第一作者及并列一作4篇）。主持黑龙江省博士后面上项目资助1项，参加国家自然科学基金3项。邮箱：jinqing@hrbmu.edu.cn

教育经历：

(1) 2018-09至2021-06,哈尔滨医科大学,人体解剖与组织胚胎学,博士

(2) 2015-09至2018-06,哈尔滨医科大学,生物医学工程,硕士

(3) 2010-09至2015-06,哈尔滨医科大学,生物信息学,学士

博士后工作经历：

(1) 2021-09至2023-09,哈尔滨医科大学，公共卫生与预防医学

讲授课程：

主讲生物信息学专业课程包括《药物毒理信息学》和《药物生物信息学》。

主持或参加的科研课题：

1. 黑龙江省人力资源和社会保障厅,面上项目, LBH-Z22207,黑龙江省博士后面上项目资助, 2022-11至2023-12, 10万元,结题,主持

   (2）国家自然科学基金委员会,面上项目, 62072144,应对突发呼吸道传染疫情的潜在治疗药物人工智能筛选, 2021-01-01至2024-12-31, 59万元,在研,参与

   (3）国家自然科学基金委员会,面上项目, 61971166,基于化学活性基团和蛋白结构域的表型关联网络识别天然产物作用谱, 2020-01-01至2023-12-31, 65万元,资助期满,参与

   (4）国家自然科学基金委员会,青年科学基金项目, 61802090,基于肿瘤异质性的耐药机制研究及抗肿瘤联合用药分子的识别, 2019-01-01至2021-12-31, 26万元,结题,参与

   近年主要研究论文：

2. Jin Q, Zhang X, Huo D, Xie H, Zhang D, Liu L, Zhao Y, Chen X. Predicting drug synergy using a network propagation inspired machine learning framework. Brief Funct Genomics. 2024 Jan 5:elad056. doi: 10.1093/bfgp/elad056. Epub ahead of print. PMID: 38183214.

3. Qing Jin; Kexin Yu; Xianze Zhang; Diwei Huo; Denan Zhang; Lei Liu; Hongbo Xie; Binhua Liang; Xiujie Chen ; Network propagation-based identification of oligometastatic biomarkers in metastatic colorectal cancer, Current Bioinformatics, 2023, 19(2): 129-143

4. Qing Jin; Binhua Liang; Xiujie Chen; Huiwen Liu ; Identification of Risk MolecularSubtype of Colon Cancer with Lymphovascular Invasion, CURRENT BIOINFORMATICS, 2021.春季, 16(8): 1034-1047

5. Qing Jin; Xiangqiong Liu; Xiusen Bian; Yunfeng Wang; Lei Liu; Hongzhe Ma; Fujian Tan; Mingliang Gu; Xiujie Chen ; Large-Scale Analysis of Drug Side Effects via Complex Regulatory Modules Composed of microRNAs, Transcription Factors and Gene Sets,SCIENTIFIC REPORTS, 2017, 7(11): 5962

6. Lei Liu; Zhuo Shao; Jiaxuan Lv; Fei Xu; Sibo Ren;Qing Jin; Jingbo Yang; Weifang Ma; Hongbo Xie; Denan Zhang; Xiujie Chen ; Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis,Frontiers in Bioengineering and Biotechnology, 2020, 8: 1-13

7. Zhang D, Liu L, Pang L,Jin Q, Ke K, Hu M, Yang J, Ma W, Xie H, Chen X. Biological evaluation and energetic analyses of novel GSK-3β inhibitors. J Cell Biochem. 2018 Apr;119(4):3510-3518. doi: 10.1002/jcb.26522. Epub 2017 Dec 26. PMID: 29144001.

8. Zhang D, Huo D, Xie H, Wu L, Zhang J, Liu L,Jin Q, Chen X. CHG: A Systematically Integrated Database of Cancer Hallmark Genes. Front Genet. 2020 Feb 5;11:29. doi: 10.3389/fgene.2020.00029. PMID: 32117445; PMCID: PMC7013921.

9. Wang Y, Su Y, Zhao K, Huo D, Du Z, Wang Z, Xie H, Liu L,Jin Q, Ren X, Chen X, Zhang D. A deep learning drug screening framework for integrating local-global characteristics: A novel attempt for limited data. Heliyon. 2024 Jul 14;10(14):e34244. doi: 10.1016/j.heliyon.2024.e34244. PMID: 39130417; PMCID: PMC11315141.

10. Cheng J, Xiao M, Meng Q, Zhang M, Zhang D, Liu L,Jin Q, Fu Z, Li Y, Chen X, Xie H. Decoding temporal heterogeneity in NSCLC through machine learning and prognostic model construction. World J Surg Oncol. 2024 Jun 13;22(1):156. doi: 10.1186/s12957-024-03435-0. PMID: 38872167; PMCID: PMC11170806.

11. Liu L, Chen X, Hu C, Zhang D, Shao Z,Jin Q, Yang J, Xie H, Liu B, Hu M, Ke K. Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network. Sci Rep. 2018 May 31;8(1):8440. doi: 10.1038/s41598-018-26783-w. PMID: 29855504; PMCID: PMC5981615.

12. Xie H, Zeng D, Chen X, Huo D, Liu L, Zhang D,Jin Q, Ke K, Hu M. Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins. Oncotarget. 2017 Oct 5;8(56):95568-95576. doi: 10.18632/oncotarget.21509. PMID: 29221149; PMCID: PMC5707043.

13. Chen X, Liu L, Wang Y, Liu B, Zeng D,Jin Q, Li M, Zhang D, Liu Q, Xie H. Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues. Oncotarget. 2017 Mar 28;8(13):20679-20694. doi: 10.18632/oncotarget.11557. PMID: 27564264; PMCID: PMC5400536.

14. Xie H, Wen H, Zhang D, Liu L, Liu B, Liu Q,Jin Q, Ke K, Hu M, Chen X. Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening and in vitro biological activities study. Oncotarget. 2017 Mar 14;8(11):18118-18128. doi: 10.18632/oncotarget.15085. PMID: 28179579; PMCID: PMC5392312.

15. Wu L, Chen X, Zhang D, Zhang W, Liu L, Ma H, Yang J, Xie H, Liu B,Jin Q. IGSA: Individual Gene Sets Analysis, including Enrichment and Clustering. PLoS One. 2016 Oct 20;11(10):e0164542. doi: 10.1371/journal.pone.0164542. PMID: 27764138; PMCID: PMC5072653.