姓名：赵文媛，职称和职务：副教授
Email：zhaowenyuan@ems.hrbmu.edu.cn
个人简介：
赵文媛副教授长期从事生物信息学高通量数据分析方法的优化和结直肠癌临床转化研究，主持国家自然科学基金青年项目一项，黑龙江省自然科学基金面上项目一项，负责结题一项国自然科学基金面上项目。参与发表SCI论文30余篇，其中第一作者4篇，通讯作者18篇。积极指导本科生参与各级各类学科竞赛，获首届黑龙江省“互联网+”大学生创新创业大赛创意组三等奖一项，中国TRIZ杯创新方法大赛国家一等奖一项，美国大学生数学建模竞赛二等奖一项，全国大学生数学建模竞赛二等奖一项等。
学术兼职：
1、中国抗癌协会肿瘤标志专业委员会肿瘤测序及大数据分析专家委员会 副秘书长
2、中国抗癌协会肿瘤标志专业委员会肿瘤标志物临床转化研究协作组 委员
教育经历：
2003.9-2008.7 哈尔滨医科大学 生物技术（生物信息方向） 学士
2008.9-2013.7 哈尔滨医科大学 生物物理学 博士 （硕博连读）
工作经历（含行政职务，按时间顺序）：
2013.7-2016.9 哈尔滨医科大学生物信息科学与技术学院 讲师
2016.9-至今 哈尔滨医科大学生物信息科学与技术学院 副教授
主持的科研课题：
国家自然科学基金青年项目，61601151，左、右结肠癌系统性多维组学差异特征及耐药标志识别，2017.01-2019.12，19万元，已结题。
黑龙江省自然科学基金面上项目，C2016037，基于基因表达丰度相对秩序关系识别II期结肠癌个体化预后标志，2016.07-2019.07，6万元，已结题。
国家自然科学基金面上项目，81572935，基于药物诱导的耐药细胞系识别临床相关的肿瘤耐药分子标志与药效预测标志，2016.01-2019.12，57万元，已结题。
主持的教学课题：
黑龙江省教育科学“十四五”规划2021年度重点课题，医工结合背景下医学教育体系的研究与实践，课题编号：GJB1421258.
已发表论文：
1、Zhang Jiashuai#, Xiao Huiting#, Song Kai, Li Keru, Yuan Hengrui, Yuan Rongqiang, Yang Jia, Zhao Yuting, Chang Zhiqiang*,Zhao Wenyuan*.IndGOterm: a qualitative method for the identification of individually dysregulated GO terms in cancer. Brief Bioinform. 2022 Mar 10;23(2):bbac012. doi: 10.1093/bib/bbac012.
2、Song Kai#, Liu Chao#, Zhang Jiashuai, Yao Yang, Xiao Huiting, Yuan Rongqiang, Li Keru, Yang Jia,Zhao Wenyuan*, Zhang Yanqiao*. Integrated multi-omics analysis reveals miR-20a as a regulator for metabolic colorectal cancer. Heliyon. 2022 Mar 5;8(3):e09068. doi: 10.1016/j.heliyon.2022.e09068.
3、Zheng Hailong#, Xie Jiajing#, Song Kai, Yang Jing, Xiao Huiting, Zhang Jiashuai, Li Keru, Yuan Rongqiang, Zhao Yuting, Gu Yunyan*,Zhao Wenyuan*. StemSC: a cross-dataset human stemness index for single-cell samples. Stem Cell Res Ther. 2022 Mar 21;13(1):115. doi: 10.1186/s13287-022-02803-5.
4、Xiao Huiting#, Zhang Jiashuai#, Wang Kai#, Song Kai, Zheng Hailong, Yang Jing, Li Keru, Yuan Rongqiang,Zhao Wenyuan*, Hui Yang*. A Cancer-Specific Qualitative Method for Estimating the Proportion of Tumor-Infiltrating Immune Cells.Frontiers in immunology. 2021 May 14;12:672031. doi: 10.3389/fimmu.2021.672031.
5、Song Kai#, Cai Hao#, Zheng Hailong#, Yang Jing, Jin Liangliang, Xiao Huiting, Zhang Jiashuai, Zhao Zhangxiang, Li Xin,Zhao Wenyuan*, Li Xia*. Multilevel prioritization of gene regulators associated with consensus molecular subtypes of colorectal cancer.Briefings in bioinformatics. 2021 Sep 2;22(5):bbab077. doi: 10.1093/bib/bbab077.
6、Zheng Hailong, Song Kai, Fu Yelin, You Tianyi, Yang Jing, Guo Wenbing, Wang Kai, Jin Liangliang, Gu Yunyan, Qi Lishuang,Zhao Wenyuan*. An absolute human stemness index associated with oncogenic dedifferentiation.Briefings in bioinformatics. 2021 Mar 22;22(2):2151-2160. doi: 10.1093/bib/bbz174.
7、Kai Wang#, Kai Song#, Zhigang Ma#, Yang Yao, Chao Liu, Jing Yang, Huiting Xiao, Jiashuai Zhang, Yanqiao Zhang*&Wenyuan Zhao*. Identification of EMT-related high-risk stage II colorectal cancer and characterisation of metastasis-related genes.British Journal of Cancer. 2020 Aug;123(3):410-417. doi: 10.1038/s41416-020-0902-y. Epub 2020 May 21.
8、Yang Jing#, Song Kai#, Guo Wenbing, Zheng Hailong, Fu Yelin, You Tianyi, Wang Kai, Qi Lishuang,Zhao Wenyuan*, Guo Zheng*. A qualitative transcriptional signature for predicting prognosis and response to bevacizumab in metastatic colorectal cancer.Molecular cancer therapeutics. 2020 Jul;19(7):1497-1505. doi: 10.1158/1535-7163.MCT-19-0864. Epub 2020 May 5.
9、You Tianyi, Song Kai, Guo Wenbing, Fu Yelin, Wang Kai, Zheng Hailong, Yang Jing, Jin Liangliang, Qi Lishuang, Guo Zheng*,Zhao Wenyuan*. A Qualitative Transcriptional Signature for Predicting CpG Island Methylator Phenotype Status of the Right-Sided Colon Cancer. Frontiers in genetics.2020 Oct 29;11:971. doi: 10.3389/fgene.2020.00971.
10、Song Kai#, Lu Haibo, Jin Liangliang, Wang Kai, Guo Wenbing, Zheng Hailong, Li Keru, He Chuchu, You Tianyi, Fu Yelin, Yang Jing,Zhao Wenyuan*, Guo Zheng*. Qualitative Ras pathway signature for cetuximab therapy reveals resistant mechanism in colorectal cancer.Federation of European Biochemical Societies journal. 2020 Dec;287(23):5236-5248. doi: 10.1111/febs.15306. Epub 2020 Apr 20.
11、Wenbing Guo, Yelin Fu, Liangliang Jin, Kai Song, Ruihan Yu, Tianhao Li, Lishuang Qi, Yunyan Gu,Wenyuan Zhao*and Zheng Guo*.An Exon Signature to Estimate the Tumor Mutational Burden of Right-sided Colon Cancer Patients.Journal of Cancer. 2020 Jan 1;11(4):883-892. doi: 10.7150/jca.34363.
12、Chang Zhiqiang, Miao Xiuxiu,Zhao Wenyuan*. Identification of Prognostic Dosage-Sensitive Genes in Colorectal Cancer Based on Multi-Omics.Frontiers in Genetics. 2020 Jan 9;10:1310. doi: 10.3389/fgene.2019.01310.
13、Hanshan Xu#,Wenyuan Zhao#, Wenbing Guo, Shaodong Cao, Chao Gao, Tiantian Song, Liping Yang, Yanlong Liu, Yu Han, Lingbo Zhang, Kezheng Wang. Prediction Model Combining Clinical and MR Data for Diagnosis of Lymph Node Metastasis in Patients With Rectal Cancer. J Magn Reson Imaging. 2020 Sep 26. doi: 10.1002/jmri.27369. Epub ahead of print.
14、Hailong Zheng#,Kai Song#,Yelin Fu,Tianyi You,Jing Yang,Wenbing Guo,Kai Wang,Liangliang Jin,Yunyan Gu,Lishuang Qi,Wenyuan Zhao*,Zheng Guo*.A qualitative transcriptional signature for determining the grade of colorectal adenocarcinoma.Cancer gene therapy. 2020 Sep;27(9):680-690. doi: 10.1038/s41417-019-0139-1. Epub 2019 Oct 9. Erratum in: Cancer Gene Ther. 2019 Dec 5.
15、Yelin Fu#, Lishuang Qi#, Wenbing Guo, Liangliang Jin, Kai Song, Tianyi You, Shuobo Zhang, Yunyan Gu,Wenyuan Zhao*, Zheng Guo*.A qualitative transcriptional signature for predicting microsatellite instability status of right-sided Colon Cancer.BMC Genomics. 2019 Oct 23;20(1):769. doi: 10.1186/s12864-019-6129-8.
16、Song Kai#, Su Wei, Liu Yanlong, Zhang Jiahui, Liang Qirui, Li Na, Guan Qingzhou, He Jun, Bai Xuefeng,ZhaoWenyuan*and Guo Zheng*. Identification of genes with universally upregulated or downregulated expressions in colorectal cancer. Journal of gastroenterology and hepatology.2019 May;34(5):880-889. doi: 10.1111/jgh.14529. Epub 2018 Dec 11.
17、SongKai#, GuoYou#, WangXianlong, CaiHao, ZhengWeicheng, LiNa, SongXuekun, AoLu, GuoZheng*,ZhaoWenyuan*. Transcriptional signatures for coupled predictions of stage II and III colorectal cancer metastasis and fluorouracil-based adjuvant chemotherapy benefit.Federation of American Societies for Experimental Biology journal. 2019 Jan;33(1):151-162. doi: 10.1096/fj.201800222RRR. Epub 2018 Jun 29.
18、SongKai#,ZhaoWenyuan#*, WangWen#, ZhangNa, WangKai, ChangZhiqiang*.Individualized predictive signatures for 5-fluorouracil-based chemotherapy in right- and left-sided colon cancer.Cancer science. 2018 Jun;109(6):1939-1948. doi: 10.1111/cas.13622. Epub 2018 May 23.
19、Lishuang Qi#,Yang Li#,Yuan Qin,Gengen Shi,Tianhao Li,Jiasheng Wang,Libin Chen,Yunyan Gu,WenyuanZhao*andZheng Guo*, An individualized signature for predicting response with concordant survival benefit for lung adenocarcinoma patients receiving platinum-based chemotherapy. British Journal of Cancer, 2016.11
20、WenyuanZhao#, Beibei Chen, Xin Guo, Ruiping Wang, Zhiqiang Chang, Yu Dong, Kai Song, Wen Wang, Lishuang Qi, Yunyan Gu, Chenguang Wang, Da Yang* and Zheng Guo*,A Rank-based Transcriptional Signature for Predicting Relapse Risk of Stage II Colorectal Cancer Identified with Proper Data Sources. Oncotarget. 2016 March 7, DOI: 10.18632/oncotarget.7956
21、Hui Xu#, Xin Guo, Qiang Sun, Mengmeng Zhang, Lishuang Qi, Yang Li, Libin Chen, Yunyan Gu, Zheng Guo*andWenyuanZhao*, The influence of cancer tissue sampling on the identification of cancer characteristics, Sci Rep.2015 Oct 22;5:15474. doi: 10.1038/srep15474.
22、WenyuanZhao#, Lishuang Qi, Yao Qin, Hongwei, Beibei Chen, Ruiping Wang, Yunyan Gu, Chunyang Liu, Chenguang Wang*, Zheng Guo*. Functional comparison between genes dysregulated in ulcerative colitis and colorectal carcinoma. PLos One. 2013;8(8):e71989-e71989.
