李昕

    李昕，讲师，博士，系统生物学教研室教学秘书。

Email：lixin@hrbmu.edu.cn

个人简介：

生物医学工程博士，临床医学博士后，2024年通过哈尔滨医科大学优秀人才计划引进并入职。承担《分子系统生物学》、《智能医学决策与诊断技术》等课程的本科生教学工作。主要研究方向包括肺癌转移的多组学研究以及标志的识别。近年来在《British Journal of Cancer》、《Communications Biology》及《BMC Genomics》等杂志发表SCI论文13篇，其中以第一作者发表SCI论文4篇。

教育经历：

2012-09至2017-06,哈尔滨医科大学,生物信息学,学士

2017-09至2019-06,哈尔滨医科大学,生物医学工程,硕士（直博）

2019-09至2022-06,哈尔滨医科大学,生物医学工程,博士

工作经历：

2022-07至2024-09,暨南大学，医学部-第一临床医学院，博士后

2024-10至今，哈尔滨医科大学，生物信息科学与技术学院，讲师

已发表论文：

1. Xin Li, Yu Guo, Haihai Liang, Jinghao Wang, Lishuang Qi. Genome-wide association analysis of hypertension and epigenetic aging reveals shared genetic architecture and identifies novel risk loci.Scientific Reports, 2024 Aug 1; 14(1): 17792.

2. Shanqi Xu^#,Xin Li^#, Jianxiong Geng, Yingyue Cao, Yan Yu*,Lishuang Qi*.Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma.British Journal of Cancer, 2023 Apr;128(8):1478-1490.

3. Xin Li^#, Lefan Tang^#, Jiaxing Deng, Xiuying Qi, Juxuan Zhang, Haitao Qi, Mengyue Li, Yixin Liu, Wenyuan Zhao, Yunyan Gu,Lishuang Qi*and Xia Li*. Identifying metabolic reprogramming phenotypes with glycolysis-lipid metabolism discoordination and intercellular communication for lung adenocarcinoma metastasis.Communications Biology, 2022 Mar 17;5(1):198.

4. Xin Li, Gengen Shi, Qingsong Chu, Wenbin Jiang, Yixin Liu, Sainan Zhang, Zheyang Zhang, Zixin Wei, Fei He, Zheng Guo* andLishuang Qi*.A qualitative transcriptional signature for the histological reclassification of lung squamous cell carcinomas and adenocarcinomas.BMC Genomics, 2019 Nov 21;20(1):881.

5. Yixin Liu^#, Zhihui Wang^#, Liping Yang^#, Meng Zhang, Mengyue Li, Juxuan Zhang, Lefan Tang, Zhiyun Jiang,Xin Li, Jiaxing Deng, Qingwei Meng, Shilong Liu*, Kezheng Wang*, Lishuang Qi*. Identification of a rank-based radiomic signature with individualized prognostic value for lung adenocarcinoma in a multi-cohort study.European Journal of Radiology, 2024 Oct 17:181:111782.

6. Sainan Zhang^#, Mengyue Li^#, Yilong Tan, Juxuan Zhang, Yixin Liu, Wenbin Jiang,Xin Li, Haitao Qi, Lefan Tang, Ran Ji, Wenyuan Zhao, Yunyan Gu*,Lishuang Qi*.Identification of mutational signature for lung adenocarcinoma prognosis and immunotherapy prediction.Journal of Molecular Medicine, 2022 Dec; 100(12):1755-1769.

7. Juxuan Zhang^#, Jiaxing Deng^#, Xiao Feng, Yilong Tan,Xin Li, Yixin Liu, Mengyue Li, Haitao Qi, Lefan Tang, Qingwei Meng, Haidan Yan* andLishuang Qi*. Hierarchical identification of a transcriptional panel for the histological diagnosis of lung neuroendocrine tumors.Frontiers in Genetics, 2022 Aug 29; 13:944167.

8. Kai Song^#, Hao Cai^#, Hailong Zheng^#, Jing Yang, Liangliang Jin, Huiting Xiao, Jiashuai Zhang, Zhangxiang Zhao,Xin Li, Wenyuan Zhao, Xia Li. Multilevel prioritization of gene regulators associated with consensus molecular subtypes of colorectal cancer.Briefings in Bioinformatics, 2021 Sep 2;22(5):bbab077.

9. Zheyang Zhang^#, Sainan Zhang^#,Xin Li, Zhangxiang Zhao, Changjing Chen, Juxuan Zhang, Mengyue Li, Zixin Wei, Wenbin Jiang, Bo Pan, Ying Li, Yixin Liu, Yingyue Cao, Wenyuan Zhao, Yunyan Gu , Yan Yu*, Qingwei Meng* andLishuang Qi*. Reference genome and annotation updates lead to contradictory prognostic predictions in gene expression signatures: a case study of resected stage I lung adenocarcinoma.Briefings in Bioinformatics, 2021 May 20;22(3):bbaa081.

10. Bo Pan^#, Zi Xin Wei^#, Ju Xuan Zhang^#,Xin Li, Qing Wei Meng, Ying Yue Cao,Lishuang Qi*, and Yan Yu*.The value of AGR2 and KRT5 as an immunomarker combination in distinguishing lung squamous cell carcinoma from adenocarcinoma.Am J Transl Res,2021 May 15;13(5):4464-4476.

11. Ying Li^#, Wenbin Jiang^#, Tianhao Li, Mengyue Li,Xin Li, Zheyang Zhang, Sainan Zhang, Yixin Liu, Wenyuan Zhao, Yunyan Gu,Lishuang Qi*, Lu Ao* and Zheng Guo*. Identification of a small mutation panel of coding sequences to predict the efficacy of immunotherapy for lung adenocarcinoma.Journal of Translational Medicine, 2020 Jan 14;18(1):25.

12. Yixin Liu^#, Zheyang Zhang^#, Tianhao Li,Xin Li, Sainan Zhang, Ying Li, Wenyuan Zhao, Yunyan Gu, Zheng Guo* andLishuang Qi*.A Qualitative Transcriptional Signature for Predicting Recurrence Risk for High-Grade Serous Ovarian Cancer Patients Treated With Platinum-Taxane Adjuvant Chemotherapy.Frontiers in Oncology, 2019 Oct18;9:1094.

13. Lishuang Qi^#,Tianhao Li^#, Gengen Shi, Jiasheng Wang,Xin Li, Sainan Zhang, Libin Chen, Yuan Qin, Yunyan Gu, Wenyuan Zhao and Zheng Guo*. An individualized gene expression signature for prediction of lung adenocarcinoma metastases.Molecular Oncology, 2017 Nov;11(11):1630-1645.