吕洪超,哈尔滨医科大学,生物信息科学与技术学院,副教授。吉林大学数学学 院获理学学士学位,哈尔滨医科大学遗传学博士研究生在读。研究方向为统计遗传学和生物信息学,多年主要从事基于组学大数据的免疫性疾病发病风险预测研究。近年参与发表SCI科研论文16篇(第一作者及并列第一作者10篇)。主持国家自然科学青年基金1项,参加国家自然科学基金5项。
主持或参加科研项目(课题)情况
1.国家自然科学基金青年项目,结合疾病易感位点挖掘策略与目标区域测序技术识别中国人群炎症性肠病的致病变异,2017/01-2019/12,17万元,已结题,负责人。
2. 国家自然科学基金数学天元基金,统计遗传学,2021.01-2021.12,20万元,已结题,参加。
3. 国家自然科学基金重大研究计划培育项目,重大疾病基因组遗传大数据资源平台建设及其示范应用,2021.01-2021.12,20万元,已结题,参加。
4.国家自然科学基金青年项目,基于新一代测序数据的类风湿性关节炎相关基因和通路的群体遗传差异研究,2013/01-2015/12,18万元,已结题,参加。
代表性研究成果和学术奖励情况(共发表SCI论文16篇,仅列部分)
(1) Teng Y#, Ding Y#, Zhang M#, Chen X, Wang X, Yu H, Liu C, Lv H*, Zhang R*, Genome-wide haplotype association study identifies risk genes for non-small cell lung cancer. Journal of Theoretical Biology, 456(2018), 84–90.
(2) Lv Hongchao#, Jiang Yongshuai#, Li Jin, Zhang Mingming, Shang Zhenwei, Zheng Jiajia, Wu Xin*, Liu Panpan, Zhang Ruijie#,*, Yu Hui*. Association between polymorphisms in the promoter region of interleukin-10 and susceptibility to inflammatory bowel disease. Mol Biol Rep. 2014 Mar;41(3):1299-310.
(3) Hongchao Lv#, Mingming Zhang#, Zhenwei Shang#, Jin Li, Shanshan Zhang, Duan Lian, Ruijie Zhang,Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for Acute Myeloid Leukemia. Oncotarget, 2017, Vol.8, (No.5), pp: 7891-7899.
(4) Wang Qun#, Lv Hongchao#, Lv Wenhua#, Shi Miao#, Zhang Mingming, Luan Meiwei, Zhu Hongjie, Zhang Ruijie*, Jiang Yongshuai*. Genome-wide haplotype association study identifies BLM as a risk gene for prostate cancer in Chinese population. Tumour Biol. 2015 Apr;36(4):2703-7.
(5) Zhang Mingming#, Jiang Yongshuai#, Lv Hongchao#, Mu Hongbo#, Li Jin, Shang Zhenwei, Zhang Ruijie*. Pathway-based association analysis of two genome-wide screening data identifies rheumatoid arthritis-related pathways. Genes Immun. 2014 Oct;15(7):487-94.
(6) Jiang Yongshuai#, *, Zhang Lanying#, Kong Fanwu#, Zhang Minging#, Lv Hongchao#, Liu Guiyou, Liao Mingzhi, Feng Rennan, Li Jin, Zhang Ruijie*. MCPerm: a Monte Carlo permutation method for accurately correcting the multiple testing in a meta-analysis of genetic association studies. PLoS One.2014 Feb 21;9(2):e89212.
(7) Jiang Yongshuai#, *, Zhang Ruijie#, *, Lv Hongchao#, Li Jin#, Wang Miao, Chang Yiman, Lv Wenhua, Sheng Xin, Zhang Jingjing, Liu Panpan, Zheng Jiajia, Shi Miao, Liu Guiyou#. HGPGD: the human gene population genetic difference database. PLoS One. 2013 May 22;8(5):e64150.
(8) Shang Zhenwei#, Lv Hongchao#, Zhang Mingming#, Duan Lian#, Wang Situo, Li Jin, Liu Guiyou, Zhang Ruijie*, Jiang Yongshuai*. Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals. Oncotarget. 2015 Dec 15; 6(40):42504-14. SCI:5.166
(9) Zhang Mingming#, Mu Hongbo#, Lv Hongchao#, Duan Lian#, Shang Zhenwei#, Li Jin, Jiang Yongshuai, Zhang Ruijie*. Integrative analysis of genome-wide association studies and gene expression analysis identifies pathways associated with rheumatoid arthritis. Oncotarget. 2016 Feb 14. doi: 10.18632/oncotarget.7390. SCI:5.166
(10) Sun Wei#, Lv Wenhua#, Lv Hongchao#, Zhang Ruijie*, Jiang Yongshuai*. Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma. Tumour Biol. 2015 Aug 30. SCI:3.611