吕文华

吕文华，哈尔滨医科大学，生物信息科学与技术学院，讲师。研究方向为统计遗传学、表观遗传学和生物信息学，主要从事复杂疾病风险基因识别和药物敏感性研究。近年来发表相关SCI科研论文12篇（其中第一作者及并列一作8篇）。主持哈尔滨医科大学创新科学研究基金1项，参与国家自然科学基金面上项目1项。邮箱：lvwenhua@hrbmu.edu.cn

教育经历（按时间倒排序）：

(1) 2016-09至2019-07,哈尔滨医科大学,生物医学工程,博士

(2) 2012-09至2015-06,哈尔滨医科大学,生物医学工程,硕士

(3) 2007-09至2012-06,哈尔滨医科大学,生物技术（生物信息学方向）,学士

工作经历（科研与学术工作经历，按时间倒序排序）：

1.2020/12-至今，哈尔滨医科大学，生物信息科学与技术学院，讲师

2.2019/09-2020/12，东北农业大学，生命科学学院，讲师

主持或参加科研项目：

1、哈尔滨医科大学创新科学研究基金，2021-KYYWF-0280，早期胚胎发育基因表达图谱构建和比较基因组学研究，2021/07-2023/07，4.8万元，在研，主持。

2、国家自然科学基金面上项目，81873910，基于PD-L1分子影像学特征筛选结直肠癌免疫治疗生物学标志物和构建诊断预测模型，2019-01至2022-12 ，57万元，在研，参与。

发表论文：

近年来（2014-现在）共发表SCI科研论文12篇，其中第一作者8篇（含并列第一作者）。

1. LvWenhua, ZhangXingda ,Dong Huili ,Wu Qiong , SunBaoqing , ZhangYan . Exploring effects of DNA methylation and gene expression on pan-cancer drug response by mathematical models. Exp Biol Med (Maywood). 2021 Jul;246(14):1626-1642.

2. Lv Wenhua, Zhang Mengying, Zhu Jiang, Zhang Min, Ci Ce, Shang Shipeng, Wei Yanjun, Liu Hui, Li Xin, Zhang Yan. Exploration of drug-response mechanism by integrating genetics and epigenetics across cancers. Epigenomics, 2018 Jul;10(7):993-1010.

3. Lv Wenhua^#（并列第一作者）, Zheng Jiajia^#, Luan Meiwei^#, Shi Miao^#, Zhu Hongjie^#, Zhang Mingming, Lv Hongchao, Shang Zhenwei, Duan Lian, Zhang Ruijie, Jiang Yongshuai. Comparing the evolutionary conservation between human essential genes, human orthologs of mouse essential genes and human housekeeping genes. Brief Bioinform, 2015 Nov;16(6):922-931.

4. Lv Wenhua^#（并列第一作者）, Wang Qiuyu, Chen He, Jiang Yongshuai, Zheng Jiajia, Shi Miao, Xu Yanjun, Han Junwei, Li Chunquan, Zhang Ruijie. Prioritization of rheumatoid arthritis risk subpathways based on global immune subpathway interaction network and random walk strategy. Mol Biosyst, 2015 Nov;11(11):2986-2997.

5. LvWenhua^#（并列第一作者）, XuYongdeng^#, GuoYiying^#, YuZiqi^#, FengGuanglong^#, LiuPanpan , LuanMeiwei , ZhuHongjie, LiuGuiyou, ZhangMingming , LvHongchao, DuanLian, ShangZhenwei, LiJin, JiangYongshuai, ZhangRuijie.The drug target genes show higher evolutionary conservation than non-target genes. Oncotarget. 2016 Jan 26;7(4):4961-71.

6. ZhangRuijie^#,LvWenhua^#（并列第一作者）, LuanMeiwei^#, Zheng Jiajia^#, Shi Miao, ZhuHongjie, LiJin, LvHongchao, ZhangMingming, ShangZhenwei, DuanLian, JiangYongshuai.Genes with stable DNA methylation levels show higher evolutionary conservation than genes with fluctuant DNA methylation levels. Oncotarget. 2015 Nov 24;6(37):40235-46.

7. Wei Sun,LvWenhua^#（并列第一作者）, LvHongchao, ZhangRuijie, JiangYongshuai.Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.Tumour Biol . 2016 Feb;37(2):1845-51.

8. WangQun, LvHongchao,LvWenhua^#（并列第一作者）, ShiMiao, ZhangMingming, LuanMeiwei, ZhuHongjie, ZhangRuijie, JiangYongshuai.Genome-wide haplotype association study identifies BLM as a risk gene for prostate cancer in Chinese population. Tumour Biol. 2015 Apr;36(4):2703-7.

9. GuYue,Ci Ce , ZhangXingda, SuMu,LvWenhua,Chen Chuangeng, LiuHui , ZhangDongwei, ZhangShumei, ZhangYan. Prediction of circRNAs Based on the DNA Methylation-Mediated Feature Sponge Function in Breast Cancer. Front Bioeng Biotechnol. 2019 Nov 26;7:365.

10. ZhuJiang ,SuMu,GuYue,ZhangXingda,LvWenhua,ZhangShumei,SunZhongyi,LuHaibo,ZhangYan.Development of a method for identifying and functionally analyzing allele-specific DNA methylation based on BS-seq data. Epigenomics. 2019 Nov 1;11(15):1679-1692.

11. WuYanmeizhi ,Han Jun,Vladimirovna Kazakova Elena,Zhang Shumei,Lv Wenhua, ZhangYan, JamaspishviliEsma, SunJingxue, FangQingxiao, MengJingjing, QiaoHong.Upregulation Of Protein Tyrosine Phosphatase Receptor Type C Associates To The Combination Of Hashimoto's Thyroiditis And Papillary Thyroid Carcinoma And Is Predictive Of A Poor Prognosis.Onco Targets Ther . 2019 Oct 14;12:8479-8489.

12. ZhangRuijie, LuanMeiwei, ShangZhenwei, DuanLian, TangGuoping, ShiMiao,LvWenhua, ZhuHongjie, LiJin, LvHongchao, ZhangMingming, Liu Guiyou, ChenHe, JiangYongshuai.RADB: a database of rheumatoid arthritis-related polymorphisms. Database (Oxford) . 2014 Sep 15;2014:bau090.