张瑞杰,三级教授，硕士研究生导师。邮箱：zhangrj@ems.hrbmu.edu.cn.
主要研究方向及成果：生物信息学与大数据技术结合的自身免疫性疾病病因学研究。多年来，带领统计遗传学课题组一直在进行着类风湿性关节炎、系统性红斑狼疮等自身免疫疾病的深度数据挖掘、疾病机制研究并取得了许多重要的科研成果，在国内外重要学术刊物发表研究论文40余篇（10分以上1篇，5分以上6篇；JCR一区5篇.），主要研究成果发表在《Brief Bioinform》(SCI,影响因子11.62)、《Europe Journal of Human Genetics》(SCI,影响因子4.58)、《Mediators of Inflammation》(SCI,影响因子4.76)、《FEBS Journal》(SCI,影响因子5.54)、《Genomics》（SCI,影响因子5.7）等学术刊物上。获科研奖励5项。主持搭建了相关数据查询与分析平台4个，申请软件著作权2项。
主持科研项目：主持与参加国家级科研项目等课题10项，主持国家自然科学基金1项，主持省厅级各类课题7项，参加国家重点研发计划项目1项（课题骨干），参加国家重点基础研发计划1项（课题骨干）。
教学工作：多年累计承担研究生、本科生多轨道课程7门。发表教学法论文10篇。自建立学院以来一直任生物信息学院首席督导，负责学院教学质量监控、负责学院督导工作安排、负责学院讲课大赛选拔与培训工作，取得显著成效，为学院教学质量保障以及青年教师培养作出重要贡献。
编写教材：多年共编写教材6部（其中主编2部，副主编2部），其中包括《概率论与信息论基础》（主编）、《医学信息分析方法》（副主编）等。
主要研究论文（共发表研究论文40余篇：10分以上1篇，5分以上6篇；JCR 1区4篇.）：以下列举20篇。
1．Mintian Cui , Taotao Li , Xinwei Yan , Chao Wang , Qi Shen , Hongbiao Ren ,Liangshuang Li , andRuijie Zhang*. Blood Genomics Identifies Three Subtypes of Systemic Lupus Erythematosus: “IFN-High,” “NE-High,” and “Mixed”. Mediators of Inflammation.Volume 2021,(SCI收录IF=4.76)
2. Yanjun Ding, Mintian Cui, Jun Qian, Chao Wang , Qi Shen , Hongbiao Ren,liangshuang,Li,Fengmin Zhang* andRuijie Zhang*. Calculation of Similarity Between 26 Autoimmune Diseases Based on Three Measurements Including Network, Function, and Semantics. Frontiers in Genetics 11 November 2021 (SC IF=4.52)
3. Sun P,Zhang R*, Jiang Y, Wang X, Li J, Lv H, Tang G, Guo X, Meng X, Zhang H, Zhang R. Assessing the patterns of linkage disequilibrium in genic regions of the human genome. FEBS J. 2011 Oct;278(19):3748-55.(SCI IF：5.54)
4. Zhang X,Zhang R*, Jiang Y, Sun P, Tang G, Wang X, Lv H, Li X. The expanded human disease network combining protein-protein interaction information.Eur J Hum Genet. 2011 (SCI IF：4.81)
5. Mintian Cui , Chao Wang , Qi Shen , Hongbiao Ren, Liangshuang Li, Shuai Li , Zerun Song , Wenbo Lin andRuijie Zhang*Integrative analysis of omics summary data reveals putative mechanisms linked to different cell populations in systemiclupus erythematosus, Genomics (2022), (SCI IF=5.7 )
6.Zhang R*, Luan M, Shang Z, Duan L, Tang G, Shi M, Lv W, Zhu H, Li J, Lv H, Zhang M, Liu G, Chen H, Jiang Y*. RADB: a database of rheumatoid arthritis-related polymorphisms.Database (Oxford). 2014 Sep 15;2014.(SCI IF：3.372)
7.Yanjun Ding, Taotao Li,Xinwei Yan, Mintian Cui, Chao Wang, Situo Wang,Fengmin Zhang*,Ruijie Zhang*.Identification of hub lncRNA ceRNAs in multiple sclerosis based on ceRNA mechanisms.Frontiers in Genetics.11 November 2021 (SCI IF：3.57)
8. Lv W, Zheng J, Luan M, Shi M, Zhu H, Zhang M, Lv H, Shang Z, Duan L,Zhang R*,Jiang Y*. Comparing the evolutionary conservation between human essential genes, human orthologs of mouse essential genes and human housekeeping genes. Brief Bioinform. 015Nov;16(6):922-31. (SCI IF：11.62 )
9. Meiwei Luan, Zhenwei Shang, Yanbo Teng, Xinren Chen, Mingming Zhang, Hongchao Lv andRuijie zhang*.The shared and specific mechanism of four autoimmune diseases。Oncotarget(Immunology), 2017, Vol. 8, (No. 65), pp: 108355-108374 (SCI IF：5.008)
10.Lv W, Wang Q, Chen H, Jiang Y, Zheng J, Shi M, Xu Y, Han J, Li C*,Zhang R*. Prioritization of rheumatoid arthritis risk subpathways based on global immune subpathway interaction network and random walk strategy. Mol Biosyst. 2015 Oct 13;11(11):2986-97. (SCI IF：2.829)
11. Lv W, Xu Y, Guo Y, Yu Z, Feng G, Liu P, Luan M, Zhu H, Liu G, Zhang M,Lv H, Duan L, Shang Z, Li J, Jiang Y,Zhang R*.The drug target genes show higher evolutionary conservation than non-target genes. Oncotarget. 2016; 7: 4961-4971.(SCI IF：5.008)
12. Jiang Y*, Zhang L, Kong F, Zhang M, Lv H, Liu G, Liao M, Feng R, Li J,Zhang R*.MCPerm: a Monte Carlo permutation method for accurately correcting the multiple testing in a meta-analysis of genetic association studies. PLoS One. 2014 Feb 21;9(2):e89212. (SCI IF：3.234)
13. .Zhang MM, Jiang YS*, Lv HC, Mu HB, Li J, Shang ZW,Zhang RJ*. Pathway-based association analysis of two genome-wide screening data identifies rheumatoid arthritis-related pathways. Genes Immun. 2014 Oct;15(7):487-94. doi: 10.1038/gene.2014.48.(SCI IF：2.913)
14.Zhang M, Mu H, Shang Z, Lv H, Duan L, Li J, Chen X, Teng Y, Jiang Y*,Zhang R*. Genome-wide pathway-based association analysis identifies risk pathways associated with Parkinson's disease. Neuroscience. 2017; 340: 398-410.(SCI IF：3.231)
15.Lv H, Zhang M, Shang Z, Li J, Zhang S, Lian D,Zhang R*.Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. Oncotarget. 2017 Jan 31;8(5):7891-7899.(SCI IF：5.008)
16.Jiang Y, Zhang M, Guo X,Zhang R*.Enrichment Disequilibrium: a novel approach for measuring the degree of enrichment after gene enrichment test. Biochem Biophys Res Commun. 2012 Aug 3;424(3):563-7. doi: 10.1016/j.bbrc.2012.06.154. (SCI IF：2.406)
17. Huang C,Zhang R*,Chen Z, Jiang Y, Shang Z, Sun P, Zhang X, Li X. Predict potential drug targets from the ion channel proteins based on SVM. J Theor Biol. 2010 Feb 21;262(4):750-6. (SCI IF：2.371)
18.Zhang R, Li X*, Jiang Y, Liu G, Li C, Zhang F, Xiao Y, Gong B. Novel strategies to mine alcoholism-related haplotypes and genes by combining existing knowledge framework. Sci China C Life Sci. 2009 Feb;52(2):163-72. doi: 10.1007/s11427-009-0019-2. (SCI IF：0.691)
19.Ruijie Zhang,Peng Sun, Yongshuai Jiang, Zhiqiang. Chen, Chen. Huang，Xuehong Zhang, and Ruimin Zhang: Genome-wide haplotype association analysis and gene prioritization identify CCL3 as a risk locus for rheumatoid arthritis, Int J Immunogenet, vol. 37, pp. 273-8, 2010. (SCI IF：1.62)
20.Jiang Y,Zhang R*, Zheng J, Liu P, Tang G, Lv H, Zhang L, Shang Z, Zhan Y,Lv W, Shi M, Zhang R*. Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades.PLoS One. 2012;7(12):e51571. (SCI IF：3.73)
