科研上主要研究方向为统计遗传学方法与生物信息学、系统生物学思想结合的系统遗传学方向方法与应用研究。教研室主持国家级、省级等科研课题10余项，其中主持国家自然科学基金项目6项，黑龙江省自然科学基金4项，厅局级课题7项；近五年发表论文40余篇，其中SCI收录17篇，EI收录4篇。
国家级课题
国家自然科学基金面上项目：全基因组范围内类风湿性关节炎相关风险因子挖掘及药物靶点识别（81172842），张瑞杰
国家自然科学基金青年项目：基于新一代测序数据的类风湿性关节炎相关基因和通路的群体遗传差异研究（31200934），姜永帅
国家自然科学基金重大计划项目，基于基因大数据的类风湿性关节炎发病风险预警研究（91746113），姜永帅
国家自然科学基金青年项目：面向人类复杂疾病的eQTL模块挖掘及其meta分析方法研究（61300116），李晋
国家自然科学基金青年项目：基于生物通路的类风湿性关节炎相关风险因子识别及调控机制研究（81601422），张明明
国家自然科学基金青年项目：结合疾病易感位点挖掘策略与目标区域测序技术识别中国人群炎症性肠病的致病变异（81600403），吕洪超
省部级课题
黑龙江省自然科学基金：利用生物信息融合技术整合多层次数据研究RA遗传机制（C201206），张瑞杰
黑龙江省自然科学基金：基于生物标记的复杂多基因挖掘与定位的生物信息融合方法的研究（F2008-02），张瑞杰
黑龙江省自然科学基金：全基因组meta-eQTL模型挖掘人类复杂疾病风险模块（QC2013C063），李晋
黑龙江省自然科学基金：基于多组学数据研究类风湿性关节炎患病风险（C2016036），姜永帅
厅局级课题
黑龙江教育厅课题：用生物信息融合技术发现药物靶点，张瑞杰
哈尔滨医科大学科学基金：疾病相关的离子通道靶点识别的生物信息平台建设，张瑞杰
黑龙江省卫生厅科技项目：KEGG通路的群体遗传多样性研究（2011-250），姜永帅
科研论文及著作
1.Zhang M, Mu H, Shang Z, Kang K, Lv H, Duan L, Li J, Chen X, Teng Y, Jiang Y,Zhang R. Genome-wide pathway-based association analysis identifies risk pathwaysassociated with Parkinson's disease. Neuroscience. 2017 Jan 6;340:398-410.SCI:3.277
2.Lv H, Zhang M, Shang Z, Li J, Zhang S, Lian D, Zhang R. Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloidleukemia. Oncotarget. 2017 Jan 31;8(5):7891-7899. SCI:5.166
3.Xu J, Liu D, Zhao L, Li Y, Wang Z, Chen Y, Lei C, Gao L, Kong F, Yuan L, JiangY. EWAS: epigenome-wide association studies software 1.0 - identifying theassociation between combinations of methylation levels and diseases. Sci Rep.2016 Nov 28;6:37951.SCI:4.259
4.Zhao L, Liu D, Xu J, Wang Z, Chen Y, Lei C, Li Y, Liu G, Jiang Y. Theframework for population epigenetic study. Brief Bioinform. 2016 Oct 19. pii:bbw098.SCI:5.134
5.Li J, Wang L, Jiang T, Wang J, Li X, Liu X, Wang C, Teng Z, Zhang R, Lv H, GuoM. eSNPO: An eQTL-based SNP Ontology and SNP functional enrichment analysisplatform. Sci Rep. 2016 Jul 29;6:30595.SCI:4.259
6.Zhang M, Mu H, Lv H, Duan L, Shang Z, Li J, Jiang Y, Zhang R. Integrativeanalysis of genome-wide association studies and gene expression analysisidentifies pathways associated with rheumatoid arthritis. Oncotarget. 2016 Feb23;7(8):8580-9.SCI:5.166
7.Lv W, Xu Y, Guo Y, Yu Z, Feng G, Liu P, Luan M, Zhu H, Liu G, Zhang M, Lv H,Duan L, Shang Z, Li J, Jiang Y, Zhang R. The drug target genes show higherevolutionary conservation than non-target genes. Oncotarget. 2016 Jan26;7(4):4961-71. SCI:5.166
8.Shang Z, Lv H, Zhang M, Duan L, Wang S, Li J, Liu G, Ruijie Z, Jiang Y.Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 andTG genes associated with Alzheimer's disease in Caribbean Hispanic individuals.Oncotarget. 2015 Dec 15;6(40):42504-14.SCI:5.166
9.Zhang R, Lv W, Luan M, Zheng J, Shi M, Zhu H, Li J, Lv H, Zhang M, Shang Z,Duan L, Jiang Y. Genes with stable DNA methylation levels show higherevolutionary conservation than genes with fluctuant DNA methylation levels.Oncotarget. 2015 Nov 24;6(37):40235-46. SCI:5.166
10.Sun W, Lv W, Lv H, Zhang R, Jiang Y. Genome-wide haplotype associationanalysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma. Tumour Biol. 2016 Feb;37(2):1845-51.SCI:3.65
11.Lv W, Zheng J, Luan M, Shi M, Zhu H, Zhang M, Lv H, Shang Z, Duan L, Zhang R, Jiang Y. Comparing the evolutionary conservation between human essential genes,human orthologs of mouse essential genes and human housekeeping genes. BriefBioinform. 2015 Nov;16(6):922-31.SCI:5.134
12.Li J, Huang D, Guo M, Liu X, Wang C, Teng Z, Zhang R, Jiang Y, Lv H, Wang L. A gene-based information gain method for detecting gene-gene interactions incase-control studies. Eur J Hum Genet. 2015 Nov;23(11):1566-72.SCI:4.287
13.Wang Q, Lv H, Lv W, Shi M, Zhang M, Luan M, Zhu H, Zhang R, Jiang Y.Genome-wide haplotype association study identifies BLM as a risk gene forprostate cancer in Chinese population. Tumour Biol. 2015 Apr;36(4):2703-7.SCI:3.65
14.Zhang R, Luan M, Shang Z, Duan L, Tang G, Shi M, Lv W, Zhu H, Li J, Lv H,Zhang M, Liu G, Chen H, Jiang Y. RADB: a database of rheumatoid arthritis-relatedpolymorphisms. Database (Oxford). 2014 Sep 15;2014. pii: bau090.SCI:3.29
15.Jiang Y, Zhang L, Kong F, Zhang M, Lv H, Liu G, Liao M, Feng R, Li J, ZhangR. MCPerm: a Monte Carlo permutation method for accurately correcting themultiple testing in a meta-analysis of genetic association studies. PLoS One.2014 Feb 21;9(2):e89212.SCI:3.23
16.Zhan Y, Zhang R, Lv H, Song X, Xu X, Chai L, Lv W, Shang Z, Jiang Y, Zhang R.Prioritization of candidate genes for periodontitis using multiple computational tools. J Periodontol. 2014 Aug;85(8):1059-69.SCI:3.03
17.Lv H, Jiang Y, Li J, Zhang M, Shang Z, Zheng J, Wu X, Liu P, Zhang R, Yu H.Association between polymorphisms in the promoter region of interleukin-10 andsusceptibility to inflammatory bowel disease. Mol Biol Rep. 2014Mar;41(3):1299-310.SCI:2.02
18.Jiang Y, Zhang R, Lv H, Li J, Wang M, Chang Y, Lv W, Sheng X, Zhang J, Liu P,Zheng J, Shi M, Liu G. HGPGD: the human gene population genetic differencedatabase. PLoS One. 2013 May 22;8(5):e64150.SCI:3.53
19.Jiang Y, Zhang R, Zheng J, Liu P, Tang G, Lv H, Zhang L, Shang Z, Zhan Y, Lv W, Shi M, Zhang R. Meta-analysis of 125 rheumatoid arthritis-related singlenucleotide polymorphisms studied in the past two decades. PLoS One.2012;7(12):e51571.SCI:3.53
20.Li J, Wang L, Xu L, Zhang R, Huang M, Wang K, Xu J, Lv H, Shang Z, Zhang M,Jiang Y, Guo M, Li X. DBGSA: a novel method of distance-based gene set analysis. J Hum Genet. 2012 Oct;57(10):642-53.SCI:2.47
21.Sun P, Zhang R, Jiang Y, Wang X, Li J, Lv H, Tang G, Guo X, Meng X, Zhang H, Zhang R. Assessing the patterns of linkage disequilibrium in genic regions of thehuman genome. FEBS J. 2011 Oct;278(19):3748-55.SCI:3.9
22.Zhang X, Zhang R, Jiang Y, Sun P, Tang G, Wang X, Lv H, Li X. The expandedhuman disease network combining protein-protein interaction information. Eur JHum Genet. 2011 Jul;19(7):783-8.SCI:4.287
23.Lian Duan, Zhendong Wang , Jingling Shen, Zhiyan Shan, Xinghui Shen, Yanshuang Wu, Ruizhen Sun, Tong Li, Rui Yuan, Qiaoshi Zhao, Guangyu Bai, Yanli Gu, Lianhong Jin, Lei Lei. Comparison of Reprogramming Genes in Induced Pluripotent Stem Cells and Nuclear Transfer Cloned Embryos. Stem Cell Rev. 2014 Aug;10(4):548-60.SCI:3.11
24.Lian Duan, Rui Liang, Zhendong Wang, Lei Lei, Lianhong Jin, Jingling Shen, Shoude Jin. Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive pulmonary disease: a meta-analysis. Mol Biol Rep. 2014 Sep;41(9):6297-303.SCI:2.02
25.Zhendong Wang, Lian. Duan, Jingling Shen #, Ruizhen Sun, Wang Xu, Zhang Xin, Lei Lei, Lianhong Jin, Shoude Jin *. Association between the interleukin-4, interleukin-13 polymorphisms and asthma: a meta-analysis. Mol Bio Rep. 2013, 40(2): 1365-1376.SCI:2.02
26.Ruijie Zhang, Lian. Duan, Yongshuai Jiang, Xuehong Zhang, Peng Sun, Jin Li, Mingming Zhang, Guoping Tang, Xing Wang, Xia Li *. Association between the IL7R T244I polymorphism and multiple sclerosis: a meta-analysis. Mol Bio Rep. 2011, 38: 5079-5084.SCI:2.02
