宁尚伟

宁尚伟，教授，博士生导师，博士后合作导师，“龙江学者”青年学者，哈医大星联教授，哈医大二院双聘教授，省高层次人才。担任学院党委委员、党总支书记（副处级），黑龙江省寒地重大疾病重点实验室副主任、大数据中心副主任。

联系方式：ningsw@ems.hrbmu.edu.cn

宁尚伟教授担任国家自然科学基金（重大专项、面上、青年项目）评审专家、中国生物信息学学会生物数据资源专委会副主任委员、黑龙江省生物信息学会党支部书记、中国计算机学会生物信息学专委会通讯委员、中国自动化学会智能健康与生物信息学专委会委员、中国生物工程学会计算生物学与生物信息学专委会委员、中国生物医学工程学会医学人工智能分会委员等。

宁尚伟教授目前共发表SCI论文110余篇，其中第一、通讯作者90余篇（含并列），包括《Nature Communications》、18篇《Nucleic Acids Research》、4篇《Briefings in Bioinformatics》、2篇《Genomics, Proteomics & Bioinformatics》、《Oncogene》等知名期刊论文，累计影响因子超过700，影响因子>10的论文25篇，h-index：29；6篇论文被评为ESI高被引论文，累计引用次数超过3200次（Google Scholar），单篇引用超过100次的论文6篇（单篇最高引用347次），获得Wiley中国作者高被引论文奖；主持国家自然科学基金3项，主持黑龙江省优青项目、黑龙江省青年创新基金、少帅揭榜杰出青年基金、于维汉杰出青年基金、中国博士后特助等课题14项，参与科技创新2030-“脑科学与类脑研究”重大项目、国家重点研发计划、973和863项目等4项；获得教育部自然科学奖二等奖、黑龙江省自然科学奖一等奖、黑龙江省教育成果特等奖、中华医学科技奖三等奖、黑龙江省自然科学奖二等奖等8项省部级奖励。

宁尚伟教授是哈尔滨医科大学生物信息学院2003年招收的第一届生物信息学专业本科生，2013年获得博士学位并留校工作（导师：李霞教授），在生物信息学领域学习和工作超过20年。宁尚伟教授带领一支超过40人的跨学科青年创新研究团队，团队成员涵盖生物信息、医学、分子生物和计算机等多个医工交叉学科，包括教授2人、研究员1人、副主任医师2人、副教授2人、博士后2人，博士和硕士研究生30余人，在癌症生物信息学研究领域积累了丰富的研究经验。主要研究方向为肿瘤生物信息学算法开发、生物医学大数据挖掘和医学影像人工智能处理等。近年来，一直致力于癌症和免疫衰老的关联研究，开发了多个基于组学大数据解析癌症复杂衰老机制的算法和数据库，在癌症和衰老研究中取得了一系列研究进展。

宁尚伟教授发表的部分学术论文（#为第一作者，*为通讯作者）:

1. Ting-Ting Gong#, Shuang Guo#, Fang-Hua Liu, Yun-Long Huo, Meng Zhang, Shi Yan, Han-Xiao Zhou, Xu Pan, Xin-Yue Wang, He-Li Xu, Ye Kang, Yi-Zi Li, Xue Qin, Qian Xiao, Dong-Hui Huang, Xiao-Ying Li, Yue-Yang Zhao, Xin-Xin Zhao, Ya-Li Wang, Xiao-Xin Ma, Song Gao, Yu-Hong Zhao,Shang-Wei Ning*, Qi-JunWu*. Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes.Nature Communications 2023. (通讯作者)

2. Shuang Guo#, Yuwei Liu#, Yue Sun, Hanxiao Zhou, Yue Gao, Peng Wang, Hui Zhi, Yakun Zhang, Jing Gan, andShangwei Ning*. Metabolic-Related Gene Prognostic Index for Predicting Prognosis, Immunotherapy Response, and Candidate Drugs in Ovarian Cancer.Journal of Chemical Information and Modeling 2024. (通讯作者)

3. Yue Gao#, Xinyue Wang#, Longlong Dong#, Changfan Qu, Qianyi Lu, Peng Wang, Mengyu Xin, Wen Zheng, Chenyu Liu,Shangwei Ning*. Identifying immune checkpoint-related lncRNA biomarkers for immunotherapy response and prognosis in cancers.Scientific Data 2023. (通讯作者)

4. Xinyue Wang, Shuang Guo, Hanxiao Zhou, Yue Sun, Jing Gan, Yakun Zhang, Wen Zheng, Caiyu Zhang, Peng Wang, Hui Zhi, Yue Gao, Xiaofeng Chen*andShangwei Ning*. Pan-cancer transcriptomic analysis identified six classes of immunosenescence genes revealed molecular links between aging, immune system and cancer.Genes & Immunity 2023. (通讯作者)

5. Xu Pan#, Caiyu Zhang#, Junwei Wang#, Peng Wang , Yue Gao, Shipeng Shang, Shuang Guo, Xin Li*, Hui Zhi* andShangwei Ning*. Epigenome signature as an immunophenotype indicator prompts durable clinical immunotherapy benefits in lung adenocarcinoma.Briefings in Bioinformatics2022.(通讯作者)

6. Yue Gao#, Shipeng Shang#, Shuang Guo#, Xinyue Wang#, Hanxiao Zhou, Yue Sun, Jing Gan, Yakun Zhang, Xia Li*,Shangwei Ning*, Yunpeng Zhang*. AgingBank: a manually curated knowledgebase and high-throughput analysis platform that provides experimentally supported multi-omics data relevant to aging in multiple species.Briefings in Bioinformatics2022.(通讯作者)

7. Xinyue Wang, Shuang Guo, Hanxiao Zhou, Yue Sun, Jing Gan, Yakun Zhang, Wen Zheng, Caiyu Zhang, Xiaoxi Zhao, Jiebin Xiao, Li Wang, Yue Gao* andShangwei Ning*. Immune pathways with aging characteristics improve immunotherapy benefits and drug prediction in human cancer.Cancers 2023. (通讯作者)

8. Xin Li#, Yuanyuan Fu#, Yue Gao, Shipeng Shang, Shuang Guo, Hanxiao Zhou, Shuqiang Qu*,Shangwei Ning*. DNA methylation dynamics of long noncoding RNA during human fetal development.Epigenomics2021. (通讯作者)

9. Yue Sun#, Yakun Zhang#, Jing Gan, Hanxiao Zhou, Shuang Guo, Xinyue Wang, Caiyu Zhang, Wen Zheng, Xiaoxi Zhao, Xia Li*, Li Wang*,Shangwei Ning*. Comprehensive quantitative radiogenomic evaluation reveals novel radiomic subtypes with distinct immune pattern in glioma.Computers in Biology and Medicine 2024. (通讯作者)

10. Yakun Zhang#, Yue Sun#, Jing Gan, Hanxiao Zhou, Shuang Guo, Xinyue Wang, Caiyu Zhang, Wen Zheng, Xiaoxi Zhao, Yunpeng Zhang*,Shangwei Ning*, Xia Li*. Reconstructing the immunosenescence core pathway reveals global characteristics in pan‑cancer.Cancer Immunology, Immunotherapy 2023. (通讯作者)

11. Shangwei Ning#, Jizhou Zhang#, Peng Wang, Hui Zhi, Jianjian Wang, Yue Liu, Yue Gao, Maoni Guo, Ming Yue, Lihua Wang* and Xia Li*. Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers.Nucleic Acids Research 2016.(第一作者)

12. Shangwei Ning#, Zuxianglan Zhao#, Jingrun Ye#, Peng Wang, Hui Zhi, Ronghong Li, Tingting Wang and Xia Li*. LincSNP: a database of linking disease-associated SNPs to human large intergenic non-coding RNAs.BMC Bioinformatics 2014.(第一作者)

13. Shangwei Ning#, Ming Yue#, Peng Wang#, Yue Liu, Hui Zhi, Yan Zhang, Jizhou Zhang, Yue Gao, Maoni Guo, Dianshuang Zhou, Xin Li and Xia Li*. LincSNP 2.0: an updated database for linking disease-associated SNPs to human long non-coding RNAs and their TFBSs.Nucleic Acids Research2017.(第一作者)

14. Yue Gao#, Xin Li#, Shipeng Shang#, Shuang Guo#, Peng Wang , Dailin Sun, Jing Gan,Jie Sun, Yakun Zhang, Junwei Wang, Xinyue Wang, Xia Li *, Yunpeng Zhang* andShangwei Ning*. LincSNP 3.0: an updated database for linking functional variants to human long non-coding RNAs, circular RNAs and their regulatory elements.Nucleic Acids Research 2021.(通讯作者)

15. Hanxiao Zhou#, Yue Gao, Xin Li, Shipeng Shang, Peng Wang, Hui Zhi, Shuang Guo, Dailin Sun, Hongjia Liu, Xia Li*, Yunpeng Zhang* andShangwei Ning*. Identifying and characterizing lincRNA genomic clusters reveals its cooperative functions in human cancer.Journal of Translational Medicine2021.(通讯作者)

16. Dianshuang Zhou, Xin Li, Shipeng Shang, Hui Zhi, Peng Wang, Yue Gao andShangwei Ning*. Prioritizing cancer lncrna modulators via integrated lncrna-mrna network and somatic mutation data.Current Bioinformatics 2022. (通讯作者)

17. Shangwei Ning#, Peng Wang#, Jingrun Ye#, Xiang Li#, Ronghong Li, Zuxianglan Zhao, Xiao Huo, Li Wang, Feng Li and Xia Li*. A global map for dissecting phenotypic variants in human lincRNAs.Eur J Hum Genet 2013.(第一作者)

18. Yakun Zhang, Jiajun Zhou, Yitong Jin, Chenyu Liu, Hanxiao Zhou, Yue Sun, Han Jiang, Jing Gan, Caiyu Zhang, Qianyi Lu, Yetong Chang, Yunpeng Zhang, Xia Li* andShangwei Ning*. Single-Cell and Bulk Transcriptomics Reveal the Immunosenescence Signature for Prognosis and Immunotherapy in Lung Cancer.Cancers 2024. (通讯作者)

19. Shuang Guo, Xinyue Wang, Hanxiao Zhou, Yue Gao, Peng Wang, Hui Zhi, Yue Sun, Yangyang Hao, Jing Gan, Yakun Zhang, Jie Sun, Wen Zheng, Xiaoxi Zhao, Yun Xiao* andShangwei Ning*. Identification and Characterization of Immunogene-Related Alternative Splicing Patterns and Tumor Microenvironment Infiltration Patterns in Breast Cancer.Cancers2022. (通讯作者)

20. Shuang Guo, Xinyue Wang, Hanxiao Zhou, Yue Gao, Peng Wang, Hui Zhi, Yue Sun, Yakun Zhang, Jing Gan, Yun Xiao* andShangwei Ning*. PD-L1-Mediated Immunosuppression in Hepatocellular Carcinoma: Relationship with Macrophages Infiltration and Inflammatory Response Activity.Biomolecules 2022.(通讯作者)

21. Lan Mei#, Yaopan Hou#, Jiajun Zhou, Yetong Chang, Yuwei Liu, Di Wang, Yunpeng Zhang*,Shangwei Ning*, Xia Li*. AVM: A Manually Curated Database of Aerosol-transmitted Virus Mutations, Human Diseases, and Drugs.Genomics, Proteomics & Bioinformatics 2024. (通讯作者)

22. Qiuyan Guo#, Qian Liu#, Danni He#, Mengyu Xin#, Yifan Dai, Rui Sun, Houxing Li, Yujie Zhang, Jiatong Li, Congcong Kong, Yue Gao, Hui Zhi, Feng Li*,Shangwei Ning*, Peng Wang*. LnCeCell 2.0: an updated resource for lncRNA-associated ceRNA networks and web tools based on single-cell and spatial transcriptomics sequencing data.Nucleic Acids Research2025.(通讯作者)

23. Peng Wang#, Qiuyan Guo#, Yangyang Hao#, Qian Liu#, Yue Gao, Hui Zhi, Xin Li,Shipeng Shang, Shuang Guo, Yunpeng Zhang*,Shangwei Ning*and Xia Li*. LnCeCell: a comprehensive database of predicted lncRNA-associated ceRNA networks at single-cell resolution.Nucleic Acids Research 2021.(通讯作者)

24. Qiuyan Guo#, Peng Wang#, Qian Liu#, Yangyang Hao#, Yue Gao, Yue Qi, Rongji Xu, Hongyan Chen, Mengyu Xin, Xiaoting Wu, Rui Sun, Hui Zhi , Yunpeng Zhang*,Shangwei Ning*and Xia Li*. CellTracer: a comprehensive database to dissect the causative multilevel interplay contributing to cell development trajectories.Nucleic Acids Research 2023.(通讯作者)

25. Jianjian Wang#, Shuang Li#, Tianfeng Wang#, Si Xu#, Xu Wang, Xiaotong Kong, Xiaoyu Lu, Huixue Zhang, Lifang Li, Meng Feng,Shangwei Ning*, Lihua Wang*. RNA2Immune: a database of experimentally supported data linking non-coding RNA regulation to the immune system.Genomics, Proteomics & Bioinformatics 2022. (通讯作者)

26. Xu Pan#, Xin Li#, Jie Sun, Zhiying Xiong, Haoyu Hu,Shangwei Ning*and Hui Zhi*. Enhancer methylation dynamics drive core transcriptional regulatory circuitry in pan-cancer.Oncogene 2022. (通讯作者)

27. Xin Li#, Xu Pan#, Hanxiao Zhou#, Peng Wang, Yue Gao, Shipeng Shang, Shuang Guo, Jie Sun, Zhiying Xiong,Shangwei Ning*, Hui Zhi* and Xia Li*. Comprehensive characterization genetic regulation and chromatin landscape of enhancer-associated long non-coding RNAs and their implication in human cancer.Briefings in Bioinformatics2022. (通讯作者)

28. Xu Pan#, Xin Li#,Shangwei Ning*and Hui Zhi*. Inferring SARS-CoV-2 functional genomics from viral transcriptome with identification of potential antiviral drugs and therapeutic targets.Cell Biosci2021.(通讯作者)

29. Wenbiao Xiao#, Yuze Cao#, Hongyu Long, Zhaohui Luo, Shuyu Li, Na Deng, Jianjian Wang, Xiaoyan Lu, Tianfeng Wang,Shangwei Ning*, Lihua Wang*, Bo Xiao*. Genome-Wide DNA Methylation Patterns Analysis of Noncoding RNAs in Temporal Lobe Epilepsy Patients.Molecular Neurobiology 2018.(通讯作者)

30. Hui Zhi#, Xin Li#, Peng Wang#, Yue Gao, Baoqing Gao, Dianshuang Zhou, Yan Zhang, Maoni Guo, Ming Yue, Weitao Shen,Shangwei Ning*, Lianhong Jin*, Xia Li*. Lnc2Meth: a manually curated database of regulatory relationships between long non-coding RNAs and DNA methylation associated with human disease.Nucleic Acids Research 2018. (通讯作者)

31. Jianjian Wang#, Lifang Li#, Hanxiao Zhou#, Shuang Li#, Liting Tian#, Xinyue Wang, Danyang Li, Yue Yin,Shangwei Ning*, Lihua Wang*. Human RNA Modifications Disease Database (HRMDD): a web resource for the molecular and clinical landscape of RNA modifications in human diseases.Genes & Diseases 2022.(通讯作者)

32. Hongying Zhao#, Xiangzhe Yin#, Haotian Xu#, Kailai Liu#, Wangyang Liu, Lixia Wang, Caiyu Zhang, Lin Bo, Xicheng Lan, Shihua Lin, Ke Feng,Shangwei Ning*, Yunpeng Zhang* and Li Wang*. LncTarD 2.0: an updated comprehensive database for experimentally-supported functional lncRNA–target regulations in human diseases.Nucleic Acids Research 2023. (通讯作者)

33. Yue Gao#, Peng Wang#, Yanxia Wang#, Xueyan Ma#, Hui Zhi, Dianshuang Zhou, Xin Li, Ying Fang, Weitao Shen,Yingqi Xu,Shipeng Shang,Lihua Wang, Li Wang*,Shangwei Ning*, Xia Li*. Lnc2Cancer v2.0: updated database of experimentally supported long non-coding RNAs in human cancers.Nucleic Acids Research2019. (通讯作者)

34. Yue Gao#, Shipeng Shang#, Shuang Guo#, Xin Li, Hanxiao Zhou, Hongjia Liu, Yue Sun, Junwei Wang, Peng Wang , Hui Zhi, Xia Li*,Shangwei Ning*and Yunpeng Zhang*. Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data.Nucleic Acids Research2021.(通讯作者)

35. Jianjian Wang#, Yuze Cao#, Huixue Zhang#, Tianfeng Wang, Qinghua Tian, Xiaoyu Lu, Xiaoyan Lu, Xiaotong Kong, Zhaojun Liu, Ning Wang, Shuai Zhang, Heping Ma*,Shangwei Ning*and Lihua Wang*. NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases.Nucleic Acids Research2017. (通讯作者)

36. Ming Yue#, Dianshuang Zhou#, Hui Zhi#, Peng Wang#, Yan Zhang, Yue Gao, Maoni Guo, Xin Li, Yanxia Wang, Yunpeng Zhang*,Shangwei Ning*,Xia Li*. MSDD: a manually curated database of experimentally supported associations among miRNAs, SNPs and human diseases.Nucleic Acids Research 2018. (通讯作者)

37. Peng Wang#, Xin Li#, Yue Gao#, Qiuyan Guo#, Yanxia Wang, Ying Fang, Xueyan Ma, Hui Zhi, Dianshuang Zhou, Weitao Shen, Weisha Liu, Lihua Wang, Yunpeng Zhang*,Shangwei Ning*and Xia Li*. LncACTdb 2.0: an updated database of experimentally supported ceRNA interactions curated from low- and high-throughput experiments.Nucleic Acids Research2019. (通讯作者)

38. Peng Wang#, Qiuyan Guo#, Yue Qi#, Yangyang Hao#, Yue Gao, Hui Zhi, Yuanfu Zhang, Yue Sun, Yakun Zhang, Mengyu Xin, Yunpeng Zhang*,Shangwei Ning*and Xia Li*. LncACTdb 3.0: an updated database of experimentally supported ceRNA interactions and personalized networks contributing to precision medicine.Nucleic Acids Research2022.(通讯作者)

39. Li Wang#*, Wangyang Liu#, Kailai Liu, Lixia Wang, Xiangzhe Yin, Lin Bo, Haotian Xu, Shihua Lin, Ke Feng, Xinyu Zhou, Lin Lin, Meiting Fei, Caiyu Zhang,Shangwei Ning*and Hongying Zhao*. The dynamic dysregulated network identifies stage-specific markers during lung adenocarcinoma malignant progression and metastasis.Molecular Therapy: Nucleic Acids 2022. (通讯作者)

40. Jian Shi#, Li Wang#*, Xiangzhe Yin#, Lixia Wang, Lin Bo, Kailai Liu, Ke Feng, Shihua Lin, Yanjun Xu*,Shangwei Ning*and Hongying Zhao*. Comprehensive characterization of clonality of driver genes revealing their clinical relevance in colorectal cancer.Journal of Translational Medicine2022.(通讯作者)

41. Jianjian Wang#, Yuze Cao#, Xiaoyu Lu#, Tianfeng Wang, Shuang Li, Xiaotong Kong, Chunrui Bo, Jie Li, Xiaolong Wang, Heping Ma, Lei Li, Huixue Zhang*,Shangwei Ning*,Lihua Wang*. MicroRNAs and nervous system diseases: network insights and computational challenges.Briefings in Bioinformatics 2020.(通讯作者)

42. Shuang Li, Yuze Cao, Huixue Zhang, Xiaoyu Lu, Tianfeng Wang, Si Xu, Tongxiao Kong, Chunrui Bo, Lifang Li,Shangwei Ning*, Jianjian Wang*, Lihua Wang*. Construction of lncRNA-Mediated ceRNA Network for Investigating Immune Pathogenesis of Ischemic Stroke.Molecular Neurobiology2021. (通讯作者)

43. Changfan Qu#, Hao Cui#, Song Xiao#, LonglongDong, Qianyi Lu, Lei Zhang, PengWang, Mengyu Xin, Hui Zhi, Chenyu Liu,Shangwei Ning*, Yue Gao*. The landscape of immune checkpoint related long non-coding RNAs core regulatory circuitry reveals implications for immunoregulation and immunotherapy responses.Communications Biology 2024. (通讯作者)

44. Ruihong Wu#, Yue Gao#, Xiaoxi Zhao, Shuang Guo, Hanxiao Zhou, Yakun Zhang, Yaopan Hou, Lan Mei, Hui Zhi, Peng Wang, Xia Li*,Shangwei Ning*,Yunpeng Zhang*. Tumor biology, immune infiltration and liver function define seven hepatocellular carcinoma subtypes linked to distinct drivers, survival and drug response.Computers in Biology and Medicine 2023. (通讯作者)

45. Hongying Zhao#, Ke Feng#, Junjie Lei#, Yaopeng Shu, Lin Bo, Ying Liu, Lixia Wang, Wangyang Liu,Shangwei Ning*, Li Wang*. Identification of somatic mutation-driven enhancers and their clinical utility in breast cancer.iScience 2024. (通讯作者)