姓名：赵文媛
职称和职务：教授、硕士/博士研究生导师
Email：zhaowenyuan@ems.hrbmu.edu.cn
主要研究方向：肿瘤系统生物学
个人简介：
赵文媛教授长期从事结直肠癌临床转化研究，主持国家自然科学基金面上项目1项，青年项目1项，黑龙江省自然科学基金面上项目1项，负责结题1项国自然科学基金面上项目。参与发表SCI论文40余篇。积极指导本科生参与各级各类学科竞赛，获首届黑龙江省“互联网+”大学生创新创业大赛创意组三等奖，中国TRIZ杯创新方法大赛一等奖，美国大学生数学建模竞赛二等奖，全国大学生数学建模竞赛二等奖等。
学术兼职：
中国抗癌协会肿瘤标志专业委员会肿瘤测序及大数据分析专家委员会副秘书长2019-2022
中国抗癌协会肿瘤标志专业委员会肿瘤标志物临床转化研究协作组委员
教育经历：
2003.9-2008.7哈尔滨医科大学生物技术（生物信息方向）学士
2008.9-2013.7哈尔滨医科大学生物物理学博士（硕博连读）
工作经历（含行政职务，按时间顺序）：
2013.7-2016.8哈尔滨医科大学生物信息科学与技术学院讲师
2016.9-2023.8哈尔滨医科大学生物信息科学与技术学院副教授
2023.9-至今哈尔滨医科大学生物信息科学与技术学院教授
科研课题：
1、整合多维组学特征识别转移性结直肠癌靶向治疗药效相关功能性基因调控子，国家自然科学基金面上项目（32370716），2024.01-2027.12，50万元，在研
2、左、右结肠癌系统性多维组学差异特征及耐药标志识别，国家自然科学基金青年项目（61601151），2017.01-2019.12，19万元，已结题
3、基于药物诱导的耐药细胞系识别临床相关的肿瘤耐药分子标志与药效预测标志，国家自然科学基金面上项目（81572935），2016.01-2019.12，57万元，已结题
4、基于基因表达丰度相对秩序关系识别II期结肠癌个体化预后标志，黑龙江省自然科学基金面上项目（C2016037），2016.07-2019.07，6万元，已结题
教学课题：
黑龙江省教育科学“十四五”规划2021年度重点课题1项：医工结合背景下医学教育体系的研究与实践。
已发表论文：
1、Jia Yang, Yuting Zhao, Rongqiang Yuan, Yongtong Wang, Shiyi Wang, Zhiqiang Chang* andWenyuan Zhao*.Identifying individualized prognostic signature and unraveling the molecular mechanism of recurrence in early-onset colorectal cancer. European Journal of Medical Research. 2023;28(1):533. Published 2023 Nov 20. doi:10.1186/s40001-023-01491-y
2、Chao Liu#, Huiting Xiao# , Luying Cui #, Lin Fang, Shuling Han, Yuli Ruan,Wenyuan Zhao*and Yanqiao Zhang*. Epigenetic-related gene mutations serve as potential biomarkers for immune checkpoint inhibitors in microsatellite-stable colorectal cancer. Front Immunol. 2022 Nov 21;13:1039631. doi: 10.3389/fimmu.2022.1039631.
3、Zhang Jiashuai#, Xiao Huiting#, Song Kai, Li Keru, Yuan Hengrui, Yuan Rongqiang, Yang Jia, Zhao Yuting, Chang Zhiqiang*,Zhao Wenyuan*. IndGOterm: a qualitative method for the identification of individually dysregulated GO terms in cancer.Briefings in bioinformatics. 2022 Mar 10;23(2):bbac012. doi: 10.1093/bib/bbac012.（通讯作者，中科院1区）
4、Song Kai#, Liu Chao#, Zhang Jiashuai, Yao Yang, Xiao Huiting, Yuan Rongqiang, Li Keru, Yang Jia,Zhao Wenyuan*, Zhang Yanqiao*. Integrated multi-omics analysis reveals miR-20a as a regulator for metabolic colorectal cancer. Heliyon. 2022 Mar 5;8(3):e09068. doi: 10.1016/j.heliyon.2022.e09068.
5、Zheng Hailong#, Xie Jiajing#, Song Kai, Yang Jing, Xiao Huiting, Zhang Jiashuai, Li Keru, Yuan Rongqiang, Zhao Yuting, Gu Yunyan*,Zhao Wenyuan*. StemSC: a cross-dataset human stemness index for single-cell samples.Stem Cell Research & Therapy.2022 Mar 21;13(1):115. doi: 10.1186/s13287-022-02803-5.
6、Xiao Huiting#, Zhang Jiashuai#, Wang Kai#, Song Kai, Zheng Hailong, Yang Jing, Li Keru, Yuan Rongqiang,Zhao Wenyuan*, Hui Yang*. A Cancer-Specific Qualitative Method for Estimating the Proportion of Tumor-Infiltrating Immune Cells. Frontiers in immunology. 2021 May 14;12:672031. doi: 10.3389/fimmu.2021.672031.
7、Song Kai#, Cai Hao#, Zheng Hailong#, Yang Jing, Jin Liangliang, Xiao Huiting, Zhang Jiashuai, Zhao Zhangxiang, Li Xin,Zhao Wenyuan*, Li Xia*. Multilevel prioritization of gene regulators associated with consensus molecular subtypes of colorectal cancer. Briefings in bioinformatics. 2021 Sep 2;22(5):bbab077. doi: 10.1093/bib/bbab077.
8、Kai Wang#, Kai Song#, Zhigang Ma#, Yang Yao, Chao Liu, Jing Yang, Huiting Xiao, Jiashuai Zhang, Yanqiao Zhang* &Wenyuan Zhao*. Identification of EMT-related high-risk stage II colorectal cancer and characterisation of metastasis-related genes.British Journal of Cancer. 2020Aug;123(3):410-417. doi: 10.1038/s41416-020-0902-y. Epub 2020 May 21. PMID: 32435058; PMCID: PMC7403418.（通讯作者，中科院1区）
9、Zheng Hailong, Song Kai, Fu Yelin, You Tianyi, Yang Jing, Guo Wenbing, Wang Kai, Jin Liangliang, Gu Yunyan, Qi Lishuang,Zhao Wenyuan*. An absolute human stemness index associated with oncogenic dedifferentiation.Briefings in bioinformatics. 2021Mar 22;22(2):2151-2160. doi: 10.1093/bib/bbz174.（通讯作者，中科院1区）
10、Yang Jing#, Song Kai#, Guo Wenbing, Zheng Hailong, Fu Yelin, You Tianyi, Wang Kai, Qi Lishuang,Zhao Wenyuan*, Guo Zheng*. A qualitative transcriptional signature for predicting prognosis and response to bevacizumab in metastatic colorectal cancer. Molecular cancer therapeutics. 2020 Jul;19(7):1497-1505. doi: 10.1158/1535-7163.MCT-19-0864. Epub 2020 May 5. PMID: 32371582.
11、You Tianyi, Song Kai, Guo Wenbing, Fu Yelin, Wang Kai, Zheng Hailong, Yang Jing, Jin Liangliang, Qi Lishuang, Guo Zheng*,Zhao Wenyuan*. A Qualitative Transcriptional Signature for Predicting CpG Island Methylator Phenotype Status of the Right-Sided Colon Cancer. Frontiers in genetics. 2020 Oct 29;11:971. doi: 10.3389/fgene.2020.00971. PMID: 33193579; PMCID: PMC7658404.
12、Song Kai#, Lu Haibo, Jin Liangliang, Wang Kai, Guo Wenbing, Zheng Hailong, Li Keru, He Chuchu, You Tianyi, Fu Yelin, Yang Jing,Zhao Wenyuan*, Guo Zheng*. Qualitative Ras pathway signature for cetuximab therapy reveals resistant mechanism in colorectal cancer. Federation of European Biochemical Societies journal. 2020 Dec;287(23):5236-5248. doi: 10.1111/febs.15306. Epub 2020 Apr 20. PMID: 32216031.
13、Wenbing Guo, Yelin Fu, Liangliang Jin, Kai Song, Ruihan Yu, Tianhao Li, Lishuang Qi, Yunyan Gu,Wenyuan Zhao*and Zheng Guo*. An Exon Signature to Estimate the Tumor Mutational Burden of Right-sided Colon Cancer Patients. Journal of Cancer. 2020 Jan 1;11(4):883-892. doi: 10.7150/jca.34363. PMID: 31949492; PMCID: PMC6959028.
14、Hanshan Xu#,Wenyuan Zhao#, Wenbing Guo, Shaodong Cao, Chao Gao, Tiantian Song, Liping Yang, Yanlong Liu, Yu Han, Lingbo Zhang, Kezheng Wang. Prediction Model Combining Clinical and MR Data for Diagnosis of Lymph Node Metastasis in Patients With Rectal Cancer. J Magn Reson Imaging. 2020 Sep 26. doi: 10.1002/jmri.27369. Epub ahead of print. PMID: 32978993.
15、Hailong Zheng#, Kai Song#, Yelin Fu, Tianyi You, Jing Yang, Wenbing Guo, Kai Wang, Liangliang Jin, Yunyan Gu, Lishuang Qi,Wenyuan Zhao*, Zheng Guo*. A qualitative transcriptional signature for determining the grade of colorectal adenocarcinoma. Cancer gene therapy. 2020 Sep;27(9):680-690. doi: 10.1038/s41417-019-0139-1. Epub 2019 Oct 9. Erratum in: Cancer Gene Ther. 2019 Dec 5;: PMID: 31595030.
16、Chang Zhiqiang, Miao Xiuxiu,Zhao Wenyuan*. Identification of Prognostic Dosage-Sensitive Genes in Colorectal Cancer Based on Multi-Omics. Frontiers in Genetics. 2020 Jan 9;10:1310. doi: 10.3389/fgene.2019.01310. PMID: 31998369; PMCID: PMC6962299.
17、Yelin Fu, Lishuang Qi, Wenbing Guo, Liangliang Jin, Kai Song, Tianyi You, Shuobo Zhang, Yunyan Gu,Wenyuan Zhao*, Zheng Guo*. A qualitative transcriptional signature for predicting microsatellite instability status of right-sided Colon Cancer. BMC Genomics. 2019 Oct 23;20(1):769. doi: 10.1186/s12864-019-6129-8. PMID: 31646964; PMCID: PMC6813057.
